海珠益肝胶囊治疗HBV前C区基因突变患者的疗效观察  

Curative effect observation of Haizhu Yigan capsule on HBV pri-C gene mutation patients

作　　者：龚钰清[1] 任泽久[1] 陈悦[1] 李东[1] 朱琳[1] 盛国光[2] 

机构地区：[1]郧阳医学院附属太和医院,湖北十堰442000 [2]湖北中医学院,湖北武汉430061

出　　处：《现代中西医结合杂志》2004年第17期2265-2266,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家"九五"攻关课题重点研究项目 (96 - 90 6 - 0 8-0 1 )

摘　　要：目的　观察海珠益肝胶囊治疗HBV前C区突变慢性乙肝患者的近期疗效。方法观察海珠益肝胶囊治疗 32例HBV突变株患者的疗效 ,并同野生株组做对照 ,比较 2组肝功能、HBV -DNA定量和近期应答率的变化。结果　 2组治疗后肝功能复常率、近期应答率及HBV-DNA定量下降程度相近 ,经统计学比较无显著性差异 (P >0 .0 5 )。结论　海珠益肝胶囊对HBV前C区突变株及野生株均有作用 。Objective It is to observe the short-term curative effect of Haizhu Yigan capsule on chronic hepatitis B patients with HBV pre-C gene mutation.Methods The curative effect of Haizhu Yigan capsule on 32 patients with HBV pre-C mutants was observed and compared with the wild type group. The changes of liver function, HBV-DNA content and short-term response rate in the two groups were observed.Results The liver function getting right rate, short-term response rate and HBV-DNA content in the two groups was similar, and there was no obvious difference (P>0.05).Conclusion Haizhu Yigan capsule has effect on both HBV pre-C mutants and wild type. The short-term curative effect of the two groups is similar.

关 键 词：海殊益肝胶囊 乙型肝炎病毒 基因突变 治疗 C区基因突变 乙型肝炎病毒 

分 类 号：R259.126.2[医药卫生—中西医结合]