广东江门地区出生缺陷监测结果分析  

The analysis about the result of the birth defects monitored in Jiangmen of Guangdong.

作　　者：李顺英[1] 冯持真[1] 张艳红[2] 温洁红[1] 

机构地区：[1]广东省江门市妇幼保健院,529000 [2]广东省江门市卫生局妇幼科

出　　处：《中国优生与遗传杂志》2004年第4期99-100,119,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨产前诊断在出生缺陷监测中的作用 ,降低出生缺陷发生率及围产儿死亡率。方法　采用全国统一的疾病诊断与分类标准 ,回顾 1998年至 2 0 0 2年出生缺陷监测结果。结果　监测围产儿 33472例 ,出生缺陷 4 0 0例 ,发生率11 95‰。围产儿死亡 36 6例 ,死亡率 10 93‰ ,因出生缺陷死亡 134例 ,占 36 2 2 % ,位居死因首位。出生缺陷前五位是先天性心脏病、总唇腭裂。多指 (趾 )、胎儿水肿综合征、神经管畸形。发生率分别为 2 3 6 0 /万、17 32 /万、16 4 /万、11 0 5 /万、8 6 6 /万。孕母年龄 <2 0岁或 >35岁 ,均较其它年龄易发生出生缺陷 ,差异显著 (P <0 .0 1)。 1998年至 2 0 0 1年出生缺陷发生率逐年上升。至 2 0 0 2年反趋下降。结论　监测出生缺陷有重要意义 ,应用产前诊断可于孕早、中期诊断出生缺陷 ,及早处理 ,配合多种优生优育措施 ,减少畸胎儿出生 。Objective: To study the value of antenatal diagnosis in the monitoring of the birth defects and to reduce the morbidity of the birth defects and the mortality of perinatal fetuses. Methods: We reviewed the result of the birth defects monitored during 1998 to 2002 with the method of ICD-9. Results: There were 400 cases of birth defects in the 33472 perinatal fetuses that we monitored, the morbidity is 11.95%. And there were 366 perinatal fetuses dead, the mortality is 10.93%. 134 cases died of birth defects. It was 36.22% in all and was the primary cause that lead to death. The 5 most commed birth defects are as followed: congienital cardic diseases、total cleft lip and cleft palate、poly fingers(toes)、fetal edema syndrome、neural tube defects. Their morbidities are as followed: 23.60/10 thousands、17.32/10 thousands、16.4/10 thousands、11.05/10 thousands、8.66/10 thousands. The pregnant women that were below 20 years or more than 35 years are prone to birth defects. The difference is significant(P<0.01). The morbidity of birth defects increased from 1998 to 2001, and reduced in 2002. Conclution: The monitoring of birth defects has great meaning. We should use the perinatal diagnosis combining with other methods in diagnosis the birth defects in early and middle pregnace so as to reduce the birth of defect fetuses, to prove the quality of the population.

关 键 词：出生缺陷 围产儿 产前诊断 

分 类 号：R714.7[医药卫生—妇产科学]