术前检测宫颈癌血管生成活性与盆腔淋巴结转移的关系  

Correlation between Cervical Carcinoma and Pelvic Lymph Node Metastasis Examined by Angiogenetic Activity before Operation

作　　者：戴淼[1] 陈昭日[1] 吕秀萍[1] 栾美英[1] 任春娥[1] 李清华[1] 邵明霞[1] 张丽芹[1] 

机构地区：[1]山东潍坊医学院附属医院妇科,山东省潍坊市261031

出　　处：《中国肿瘤临床》2004年第16期911-913,共3页Chinese Journal of Clinical Oncology

基　　金：山东省教育厅科研基金资助(编号:J98k60)

摘　　要：目的探讨术前宫颈癌血管生成活性与盆腔淋巴结转移的关系。方法采用彩色多普勒血流显像(CDFI)技术检测22例宫颈癌组织血流信号定量测定阻力指数(RI),同时采用免疫组化技术血管内皮标志物FⅧ因子相关抗原(FⅧ-RA)检测宫颈癌术前活检组织和术后肿瘤内微血管密度(MVD),分析两者与盆腔淋巴结转移的关系。结果1)盆腔淋巴结转移组LN(+)组CDFI检测RI值明显低于无盆腔淋巴结转移组LN(-)组,差异有显著性(P<0.05)。2)LN(+)组MVD较LN(-)组差异有显著性(P<0.01)。而术前活检组织MVD与术后肿瘤内MVD比较无明显差异(P>0.05)。3)反映血管生成活性的RI值与MVD两者具有良好的相关性(负相关)(r=-0.78,P<0.01)。结论宫颈癌血管生成活性与盆腔淋巴结转移密切相关,血管生成活跃者淋巴结转移可能性大,CDFI对宫颈癌活体肿瘤内血流检测和术前宫颈活检组织内MVD相结合,为临床判断盆腔淋巴结转移和手术彻底清扫淋巴结提供一较为简便和理想的指标。Objective: To study the relationship between cervical carcinoma and pelvic lymph node metastasis before operation. Methods: Vascularizations of cervical carcinoma tissue from 22 cases were observed by color Doppler flow image to measure resistance index(RI) quantatively, and the biopsy specimen of the cervical carcinoma obtained before operation and the microvessel desity(MVD) were also assessed immunohitochemicaly by using the specific endothelial cell markers FⅧ-RA.The association between tumor angiogenetic activity and lymph node metastasis were studied further. Results: 1) The value of RI of pelvic lymph node metastasis LN(+) were much lower than LN(-) group(P<0.05). 2) MVD expression were higher in LN(+) group than in LN(-) group (P<0.01), but there is no difference between MVD of biopsy specimen obtained before operation and MVD of the tumor. 3) The value of RI reacting angiogenetic activity was positive correlative to MVD (r=-0.78, P<0.01). Conclusions: Cervical carcinoma angiogenetic activity is closely correlated with pelvic lymph node metastasis. CDFI and MVD of the biopsy from the tumor before operation may serve as a parameter for determining tumor metastasis potential and removing lymph node.

关 键 词：彩色多普勒超声 阻力指数 宫颈癌 新生血管化 淋巴结转移 

分 类 号：R737.33[医药卫生—肿瘤]