地塞米松对特发性血小板减少性紫癜外周血淋巴细胞凋亡及Fas/FasL的影响  

Effect of dexamethasone on apoptosis and Fas/FasL expression from peripheral blood lymphocyte in patients with idiopathic thrombocytopenic purpura

作　　者：孟琼[1] 肖红[1] 刘仿[2] 蔡康荣[3] 

机构地区：[1]广东医学院附属医院儿科,广东湛江524001 [2]广东医学院免疫学教研室,广东湛江524023 [3]广东医学院分析中心,广东湛江524023

出　　处：《广东医学院学报》2004年第4期339-340,共2页Journal of Guangdong Medical College

摘　　要：目的 :观察地塞米松对特发性血小板减少性紫癜 (ITP)外周血淋巴细胞凋亡及 Fas、Fas L表达的影响及其临床意义。方法 :用流式细胞仪检测 30例 ITP患儿治疗前后外周血淋巴细胞凋亡率及 Fas、Fas L蛋白表达。结果 :治疗前淋巴细胞凋亡率及 Fas、Fas L蛋白表达与对照组相比差异无统计学意义 (P>0 .0 5)。治疗后血小板增加时淋巴细胞凋亡率增加 ,Fas、Fas L蛋白表达上调 ,与治疗前相比差异有显著性意义 (P<0 .0 1 )。结论 :地塞米松可显著促进 ITP患儿外周血淋巴细胞的凋亡 ,上调淋巴细胞 Fas、Fas L的表达 ,有助于清除激活的淋巴细胞。Objective: To study the effect of dexamethasone on apoptosis and Fas/FasL expression from peripheral blood lymphocyte (PBL) in patients with idiopathic thrombocytopenic purpura (ITP). Methods: PBL apoptosis and Fas/FasL expression in 30 children with ITP pre- and post-treatment of dexamethasone and 22 healthy controls were deter mined by flow cytometry. Results: There were no statistical differences in PBL apoptosis and Fas/FasL expression between the untreated patients and normal controls (P>0.05), but they were significantly up-regulated post-treatment (P<0.01). Conclusion: Dexamethasone could induce PBL apoptosis and Fas/FasL overexpression in patients with ITP, which is helpful in eli minating the activated lymphocytes.

关 键 词：地塞米松 紫癜 血小板减少性 特发性 凋亡 FAS 

分 类 号：R733.7[医药卫生—肿瘤]