神经细胞黏附分子CD_(56)在肺癌中的表达  

The Expression of Neural Cell Adhesion Molecule CD_(56) in the Human Lung Cancer

作　　者：胡振红[1] 彭琪琳[2] 傅祖红[1] 司斌[1] 刘志遐[1] 

机构地区：[1]广州军区武汉总医院呼吸内科,湖北武汉430070 [2]广州军区联勤部武珞路干休所

出　　处：《中国医师杂志》2004年第9期1208-1209,共2页Journal of Chinese Physician

摘　　要：目的　研究神经细胞黏附分子 (CD56)在肺癌中的表达 ,并探讨其病理意义和作为小细胞肺癌肿瘤标志物的可能。方法　收集肺癌石蜡标本 5 9例并培养小细胞肺癌H12 8细胞 ,应用免疫组织化学的方法检测CD56的表达。结果　在 43例NSCLC组织中 ,CD56的表达 3 5例呈阴性反应 ,8例阳性反应均为弱阳性。CD56在 16例SCLC组织中的表达高达 10 0 %,且 12例 ( 80 %)呈强阳性表达。CD56在NSCLC和SCLC组织中的表达具有高度相差显著性。CD56在H12 8细胞系中呈普遍表达。Objective To study the expression of neural cell adhesion molecule CD 56 in the human lung cancer and its pathological significance. Methods 59 paraffin imbedded specimens of lung cancers were collected and human small cell lung cancer H128 cell line was cultured.The CD 56 expression in the lung cancer tissues and H128 cells was detected by immunohistochemical method. Results The expression of CD 56 was positive in 35 of 43 NSLC specimens, and the other specimens showed weakly positive staining. All 19 cases of the SCLC specimens showed CD 56 positive staining, 12 specimens of which were strongly positive. There was a significant difference in CD 56 expression between the SCLC and NSCLC. CD 56 was extensively expressed in H128 cells. Conclusion CD 56 might be an ideal tumour marker for SCLC.

关 键 词：神经细胞黏附分子 CD56 免疲组织化学 肿瘤标志物 小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]