非脑型肝豆状核变性患者与正常人记忆商数比较(英文)  

Comparison of memory quotient between non-cerebral hepatolenticular degeneration patients and normal people

作　　者：胡文彬[1] 杨广娥[1] 王共强[1] 杨任民[1] 

机构地区：[1]安徽中医学院神经病学研究所附属医院二病区,安徽省合肥市230061

出　　处：《中国临床康复》2004年第25期5384-5385,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:脑型肝豆状核变性(hepatolenticulardegeneration,HLD)患者的智力、记忆能力下降,但非脑型HLD患者的记忆能力是否有改变?目的:明确非脑型HLD患者的记忆能力。设计:以诊断为依据的病例对照研究。地点和对象:1998-01/2002-12到安徽中医学院神经病学研究所附属医院住院治疗及门诊就诊非脑型HLD患者30例(患者组),男15例,女15例,年龄16～37岁。20例对照组为身体健康的本院工作人员及社会志愿参加者,其中男13例,女7例,年龄18～43岁。干预:使用龚耀先修订的韦氏成人记忆量表(WMS)对患者组和对照组的记忆商数分别进行测试。主要观察指标:两组患者WMS测定量表得分和记忆商数。结果:患者组记忆商数(134.07±12.98)高于对照组(110.4±13.4)(P<0.01);其中非常优秀者占67%,优秀者占20%,中上者占13%。结论:非脑型HLD患者记忆能力较强,推测其机制可能为脑组织的铜含量略高于正常人,相关铜依赖酶的活性增强,脑细胞间信号传递效能增强。BACKGROUND:Patients with cerebral type hepatolenticular degeneration(HLD) always suffer from decrease of intelligence and memory.If the memory ability of non-cerebral type HLD patients changes is still uncertain. OBJECTIVE:To make sure the memory ability of non-cerebral type HLD patients.DESIGN:Case control study on the basis of diagnosis.SETTING and PARTICIPANTS:Thirty cases of non-cerebral HLD treated in Hospitalization and Outpatient Service in Neurology Research Institute of the Affiliated Hospital of Anhui College of Traditional Chinese Medicine during January 1998 to December 2002 were chosen as patient group with 15 males and 15 females,aged from 16 to 37 years old.Twenty healthy people from this hospital staff or volunteers from community were chosen as control group with 13 males and 7 females,aged from 18 to 43 years old.INTERVENTIONS:Wechsler memory scale(WMS) was used to assess the memory quotient of the patient group and the control group.MAIN OUTCOME MEASURES:Score of WMS of two groups and memory quotients.RESULTS:The memory quotient of the patient group(134.07±12.98) was higher than that of the control group(110.4±13.4)(P< 0.01).And 67%of them had excellent memory,20%had good memory,13%of them had average memory or above.CONCLUSION:The memory ability of non-cerebral HLD patient is pretty good.It is supposed that the copper content of them is a bit higher than that of normal people so that the efficiency of signal transmission among brain cells is increased due to the enhancement of activity of copper dependent enzyme.

关 键 词：非脑型肝豆状核变性 记忆商数 智力下降 记忆能力下降 

分 类 号：R742.4[医药卫生—神经病学与精神病学]