传统抗癫痫药物和托吡酯对成年癫痫患者生活质量的影响(英文)  

Impact of traditional antiepileptic and topiramate on the quality of life of adult epileptic patients

作　　者：许念桂[1] 朱丹彤[2] 肖波[2] 谢光洁[2] 

机构地区：[1]中南大学湘雅二医院神经内科,湖南省长沙市410011 [2]中南大学湘雅医院神经内科,湖南省长沙市410008

出　　处：《中国临床康复》2004年第25期5386-5388,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:托吡酯现已广泛应用于临床治疗各型癫痫,但对国内成年癫痫患者生活质量影响的报道较少。目的:比较传统抗癫痫药物和托吡酯对成年癫痫患者生活质量的影响,以探讨产生影响的机制。设计:采用随机对照的临床研究。地点和对象:中南大学湘雅二医院及湘雅医院门诊新诊断癫痫患者,共102例,其中男60例,女42例,年龄16～60岁。干预:102例临床新确诊的成年癫痫患者被随机分为两组:一组予以传统抗癫痫药物单药系统治疗(传统抗癫痫药物组,54例),另一组予以托吡酯单药治疗(托吡酯组,48例)。1个月后比较两组的发作频率和不良反应,并用QOLIE-30量表对这102例癫痫患者进行生活质量评定。主要观察指标:①两组发作频率和不良反应。②生活质量评分。结果:托吡酯组的发作频率和不良反应均明显低于传统抗癫痫药物组,其中前者有效11例,显效7例,控制16例;而后者有效13例,显效5例,控制13例。托吡酯组的生活质量总分却明显高于传统抗癫痫药物组,分别为60±13和53±15,尤其在前5个分项的评分中更加明显。结论:托吡酯能提高癫痫患者的生活质量,其改善生活质量的作用主要是通过控制发作和减轻不良反应实现的。BACKGROUND:Topiramate has been widely applied in the clinical treatment of all types of epilepsy at present.However,there are few reports about its impact on the quality of life(QOL) of domestic adult epileptic patients. OBJECTIVE:To compare the impact of traditional antiepileptic and Topiramate on the QOL of adult epileptic patients for the discussion of the relative mechanism. DESIGN:A randomized controlled clinical trial.SETTIGN and PARTICIPANTS:There were 102 epileptic patients newly diagnosed in the Outpatient Department of Xiangya Hospital and the Second Xiangya Hospital of Central South University,of which there were 60 males and 42 females aged from 16 to 60 years old. INTERVENTIONS:There were 102 newly clinical diagnosed adult epileptic patients randomly allocated into two groups: One group was treated by traditional antiepileptic single medication systemic therapy(traditional antiepileptic group,n=54) and the other group was treated by Topiramate single medicine therapy(Topiramate group,n=48).The attack frequency and adverse effect of the two groups were compared after one month and the QOL of these 102 epileptic patients were evaluated with QOLIE-30 scale. MAIN OUTCOME MEASURES:①attack frequency(AF) and adverse reaction and side effect of two groups.②QOL score.RESULTS:The AF and AE of the Topiramate group were significantly lower than that of the traditional antiepileptic group,of which there were 11 cases effective, 7 cases showing effect and 16 cases in control of the former group,and 13 cases effective,5 cases showing effect and 13 cases in control in the latter group.The QOL score of the Topiramate group was significantly higher than that of the traditional antiepileptic group,which were 60±13 and 53±15 respectively, especially in the first 5 items. CONCLUSION:Topiramate can improve the QOL of epileptic patients, which realizes its improvement of QOL through controlling the attack and reducing AE.

关 键 词：抗癫痫药物 托吡酯 成年 癫痫 生活质量 药物治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]