二醋吗啡白质脑病的临床与影像学特征(英文)  

Clinic and image features of heroin-induced spongiform leukoencephalopathy

作　　者：廖瑜[1] 刘双喜[1] 易文中[1] 周军[1] 唐建新[1] 武斌[1] 

机构地区：[1]南华大学附属怀化医院神经内科,湖南省怀化市418000

出　　处：《中国临床康复》2004年第25期5448-5449,i004,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:二醋吗啡(海洛因)引起的海绵状白质脑病是近年来出现的一种新病种,临床上对临床表现、病理改变与影像学特点分析较少。目的:探讨海洛因引起的海绵状白质脑病的临床和影像学特点。设计:以诊断为依据的回顾性研究。地点和对象:南华大学附属怀化医院神经内科收治患者6例,5例来自怀化市戒毒所,1例来自贵州省。方法:查看流行病学资料,临床实验室检查结果,体格检查,治疗资料以及头颅CT,MRI等影像学资料。主要观察指标:临床实验室检查结果以及头颅CT,MRI等影像学特点。结果:患者有吸食海洛因病史,在突然戒断复又吸食后发病,有小脑症状和白质病变的体征,CT,MRI表现为对称性片状白质损害、部位在小脑、基底核、内囊后肢和半卵圆中心,脑脊液检查为阴性。结论:海洛因引起的海绵状白质脑病有自己独特的流行病学特点,根据临床征象及特征性的影像学表现;生前诊断海洛因白质脑病是可能的。BACKGROUND:Spongiform leukoencephalopathy induced by heroin is a new disease emerged recently, which has few clinical analyses on its clinical manifestation,pathological changes and image features. OBJECTIVE:To investigate the characteristics of clinic and image in heroin-induced spongiform leukoencephalopathy. DESIGN:A retrospective investigation based on diagnosis.SETTING and SUBJECTS:Six cases admitted by the Department of Neurology of Affiliated Huaihua Hospital of Nanhua University were selected in our study,in which five of them came from Stop Drug Addiction Station of Huaihua City and the other one came from Guizhou Province.METHODS:Epidemiological data, clinical laboratory results,physical examination, therapy and some image data like CT and MRI were reviewed. MAIN OUTCOME MEASURES:The results of clinical laboratory tests as well as the features of image, such as CT and MRI,etc..RESULTS:All the patients had histories of inhalation of heroin vapour, of which the disease was onset when relapse after withdrawal suddenly.There were cerebellar symptoms and physical signs of pathological changes in white matter,which manifested in brain CT and MRI that there were symmetrical lesions in white matter that distributed in cerebellum,basal ganglion area, posterior crus of internal capsule and the semi-oval center.The results of cerebrospinal fluid tested in all samples were negative. CONCLUSION:Heroin-induced spongiform leukoencephalopathy has its own specific epidemiological characters, and therefore,the antemortem diagnosis of spongiform leukoencephalopathy may be possible based on the detailed clinical manifestations and image features.

关 键 词：二醋吗啡 诊断 影像学特征 海洛因 海绵状白质脑病 

分 类 号：R742[医药卫生—神经病学与精神病学] R595.5[医药卫生—临床医学]