粒细胞集落刺激因子在化疗前后非小细胞肺癌患者血清中的表达与临床研究  

The Clinical Investigation and Expression of G-CSF Serum Level Pre-chemotherapy and Post-chemotherapy in Patients with NSCLC

作　　者：李民[1] 吴利娜[1] 李蓉[1] 

机构地区：[1]西安市中心医院,陕西西安710003

出　　处：《实用医技杂志》2004年第09B期1805-1807,共3页Journal of Practical Medical Techniques

基　　金：西安市科技攻关项目 (YG2 0 0 1 1 2 )

摘　　要：目的 :观察化疗前后非小细胞肺癌 (NSCLC)患者血清粒细胞集落刺激因子 (G CSF)表达的差异 ,探讨其作为NSCLC肿瘤标志物指导临床疗效的价值。方法 :应用酶联免疫双抗体夹心法检测 10例化疗前后NSCLC患者血清G CSF表达水平。结果 :化疗后NSCLC患者G CSF水平显著下降 (P <0 .0 1)。结论 :G CSF是一较好的非小细胞肺癌肿瘤标志物 ,是监测病情、提示疗效的良好指标。Objective To determine the serum value of G-CSF differ ences between pre -chemotherapy and post-chemotherapy in NSCLC patients and to evaluate the clin ic al practice value of G-CSF as a new tumor marker of lung cancer to guide the ef f ect of chemotherapy.Method Serum level of G-CSF were measured by the means of EL ISA in 10 pre-chemotherapy and post-chemotherapy patients with NSCLC.R esults Ser um levels of G-CSF in patients with NSCLC pre-chemotherapy and post-chemother apy were significantly decreased(P<0.01).Conclusion G-CSF is a sensitive and specific tumor marker for the diagnosis of NSCLC,it co u ld be a good index in monitoring patients condition and predicting prognosis for NSCLC.

关 键 词：非小细胞肺癌 人粒细胞集落刺激因子 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]