大肠癌转移相关基因的研究进展  

Metastasis-associated Genes of Colorectal Carcinoma

作　　者：梁莉[1] 丁彦青[1] 

机构地区：[1]第一军医大学病理学教研室，广州市510515

出　　处：《医学分子生物学杂志》2004年第4期231-234,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金 (No 3 0 170 42 3 ) ;军队医药卫生基金( 0 1MA12 8)

摘　　要：目前有关大肠癌转移相关基因的研究进展迅速 ,据报道已有数百种基因参与大肠癌转移调控过程。本文综合近年来的研究情况 ,将其按功能分为 7类 ,主要包括运动因子、黏附分子、细胞外基质降解酶、血管增生因子、转录因子、信号转导因子及其它一些癌基因或抑癌基因 ,并对以上类型的基因在大肠癌转移过程中的作用机制进行简要叙述。Great progress has been made in studies concerning the metastasis-associated genes of colorectal carcinoma (CRC) and more than hundreds of genes have been reported to be involved in the regulations of CRC metastasis. This review summarized the current advances and functionally classified those genes into seven categories, including motility factor, adhesive factor, extracellular matrix degradative enzyme, angiogenic factor, transcription factor, signal transduction factor and other oncogenes or tumor suppressor genes. The mechanisms of these genes in the CRC metastasis were briefly discussed.

关 键 词：大肠癌 肿瘤转移 基因 

分 类 号：R735[医药卫生—肿瘤] R57[医药卫生—临床医学]