氯离子通道家族研究进展  

Advances in Research of Chloride Channel Family

作　　者：张勇[1] 杨安钢[1] 周士胜[2] 

机构地区：[1]第四军医大学生物化学与分子生物学教研室,西安市710032 [2]第四军医大学生理学教研室,西安市710032

出　　处：《医学分子生物学杂志》2004年第4期245-248,共4页Journal of Medical Molecular Biology

基　　金：国家自然科学基金 (No 3 0 2 70 60 2 ) ;教育部骨干教师基金资助 ( 2 0 0 0年 )

摘　　要：Cl-通道是指分布于细胞膜或细胞器质膜上的一些对Cl-及其它阴离子有通透性的通道蛋白。根据分子生物学和电生理学特点 ,Cl-通道分为电压门控Cl-通道、cAMP/蛋白激酶A激活的Cl-通道、细胞内Cl-通道、Ca2 + 激活的Cl-通道、容量调节的Cl-通道和配体激活的Cl-通道。这些离子通道具有调节细胞兴奋性、细胞容积大小、pH值、细胞发育及凋亡的功能。在这些Cl-通道基因中存在着多种基因突变 ,例如 :错配、缺失、插入等 ,一些突变的结果是只引起基因型的改变 ,而不改变表型 ;另外一些突变却可以引起许多遗传性疾病。Cl -channels refer to a group of proteinaceous pores in biological membranes, which can conduct chloride and other anions. According to the molecular-biological and electrophysiological properties of Cl - channels, they fall into the categories of voltage-gated chloride channels, cAMP/protein kinase A-activated chloride channels, family of intracellular Cl - channels, Ca 2+ activated chloride channels, volume-regulated anion channels. Chloride channels play a variety of roles in cells, such as regulation of excitability, cell volume, pH, development and apoptosis. A variety of mutations might take place with Cl - genes, including mismatch, deletion, insertion etc. Some mutations can alter genotype but not phenotype while others may cause hereditary diseases.

关 键 词：CL^-通道 基因突变 疾病 

分 类 号：Q754[生物学—分子生物学]