依那普利对糖尿病性视网膜病变患者眼血流影响的临床研究  

Effect of Enalapril on the ophthalmic blood flow in patients with diabetic retinopathy

作　　者：孙建西[1] 王斌[1] 史宝强[1] 张培[1] 秦继宝[1] 

机构地区：[1]连云港市东方医院,江苏连云港222042

出　　处：《眼科》2004年第4期219-222,共4页Ophthalmology in China

基　　金：连云港市科委科研基金资助 (编号 :SH0 2 13)

摘　　要：目的 :探讨血管紧张素转换酶抑制剂 (ACEI)对糖尿病患者眼部血流的影响。方法 :对非增殖期DR组 2 3例增殖期DR组 19例 ,对照组 19例检测服用ACEI前后血浆的血管紧张素Ⅱ (AngⅡ )水平 ,并应用彩色多普勒血流显像 (colorDopplerflowimaging ,CDFI)检测服药前后眼部循环的血流动力学变化 ,包括 :视网膜中央动脉 (centralretinalartery ,CRA) ,鼻侧和颞侧睫状后动脉 (posteriorcilliaryarteries,PCAs)及眼动脉 (ophthalmicartery ,OA)血流的收缩期峰速 (peaksystolicvelocity ,PSV) ,舒张末期流速 (end diastolicvelocity ,EDV)和阻力指数 (resistanceindex ,RI)。结果 :服药前DR组与正常组AngⅡ含量比较有非常显著性差异 (P <0 0 1) ;对照组服药前后AngⅡ含量、OA、CRA及PCAs血流速度差异无显著性。DR组服药前后AngⅡ含量比较差异有显著性 (P <0 0 5 )。DR组患者服药后OA血流速度较服药前略有提高 ,达不到正常标准 ,统计学处理差异无显著性 (P >0 0 5 ) ;非增殖期DR组与增殖期DR组CRA及PCAs血流速度服药后较服药前提高 ,统计学处理差异有显著性 (P <0 0 5 )。结论 :血管紧张素转换酶抑制剂 (ACEI)能改善糖尿病视网膜病变患者眼部循环。Objective:To investigate the effect of angiotensin converting enzyme inhibitor(ACEI) on the ophthalmic blood flow in patients with diabetic retinopathy(DR).Methods:Before and after taking ACEI,the serum concentration of Ang Ⅱ of patients with diabetic retinopathy was determined,and various clinical parameters including PSV(peak systolic velocity), EDV(end diastolic velocity ),RI(resistance index) of CRA(central retinal artery), PCAs (posterior cilliary arteries) and OA (ophthalmic artery) were also measured with color Doppler flow imaging.Results:Before and after taking ACEI,there was significant difference in serum concentrations of Ang Ⅱ between DR group and control group( P <0 01).There was no statistic significance for serum concentration of Ang Ⅱ and the blood flow in control group before and after study There was statistical significance for serum concentration of Ang Ⅱ in the pre and post treatment in DR group( P <0 05).The blood flow velocity of the ophthalmic artery(OA)increased a little after study,but there was no significant difference( P >0 05).The blood flow velocity of the central retinal artery(CRA) and posterior cilliary arteries(PCAs)in non proliferative group and proliferative group,were increased after treatment compared with before treatment with significant difference statistically( P <0 05).Conclusion:ACEI can improve the ophthalmic blood flow in patients with diabetic retinopathy.

关 键 词：糖尿病性视网膜病变 血流速度 依那普利 

分 类 号：R774.1[医药卫生—眼科]