柳氮磺吡啶治疗轻中型溃疡性结肠炎的的临床评价  

Clinical evaluation of sulfasalazine in the treatment of patients with mild and moderate ulcerative colitis

作　　者：陈其奎[1] 袁世珍[1] 钟英强[1] 李初俊[2] 吴惠生[3] 

机构地区：[1]中山大学第二附属医院消化科 [2]中山大学第一附属医院消化科,广州510089 [3]广州市第一人民医院消化科,广州510033

出　　处：《中国临床药理学与治疗学》2004年第9期1007-1010,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :评价柳氮磺吡啶 (SASP) 3g·d-1治疗轻中型溃疡性结肠炎的近期疗效和安全性。方法 :SASP 3次 d ,1g 次治疗 12 2例轻中型溃疡性结肠炎病人 ,6周后观察临床症状、结肠镜和病理组织学改变、总体疗效以及不良反应的发生率。结果 :12 2例轻中型溃疡性结肠炎病人中 110例完成了整个疗程。 110例病人的临床、结肠镜和病理组织学缓解率分别为 71.8% ,2 1.8%和 16 .4 % ;临床缓解的 79例病人中 ,结肠镜和病理组织学 1级占 5 8.2 %和6 7.1%。 12 2例溃疡性结肠炎病人临床显效率为6 3.9% ,总有效率为 82 .0 %。共有 2 1例 (17.2 % )发生了 1次及以上的不良反应 ,其中 4例 (3.3% )出现皮疹和白细胞减少 ,其余不良反应轻微。结论 :SASP 3g·d-1治疗轻中型溃疡性结肠炎的近期疗效和安全性较好 ,尤以临床症状改善显著 ,但临床缓解的病人中一半以上仍有结肠黏膜的轻度炎症。AIM: To investigate the short-term efficacy and safety of sulfasalazine (SASP) 3 g per day in the treatment of patients with mild and moderate ulcerative colitis (UC). METHODS: 122 patients were treated with SASP ( 1 g, t.i.d.) for 6 weeks. The data of clinical manifestations, colonoscopic and histological involvements were compared before and after the treatment of UC. The short-period efficacy and adverse reactions were evaluated in 110 patients. RESULTS: The therapeutic project was carried out in the 110 out of 122 patients. After 110 patients were treated for 6 weeks, the clinical, colonoscopic and histological remission were 71.8%, 21.8% and 16.4%, respectively. Among the 79 patients with clinical remission, 58.2% and 67.1% of them remained grade 1 in colonoscopic and histological findings, respectively. The curative rates and the effective rates were 63.9% and 82.0%, respectively. Among the 122 patients treated with SASP, 21 of them ( 17.2%) had adverse reactions. Except 4 patients suffered urticaria and leukopenia, no patients quitted the treatment because of obvious adverse reaction. CONCLUSION: SASP ( 3 g per day) can be an effective and safe medicine in treatment of patients with mild and moderate UC, but more than half of the patients in clinical remission still have light inflammation in colonoscopy and histology.

关 键 词：药效学 不良反应 柳氮磺吡啶 溃疡性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]