蒙旦树脂醇类生物活性物质的研究  

STUDY ON BIOACTIVE CONSTITUENTS IN ALCOHOLIC FRACTIONS OF MONTAN RESINS FROM BROWN COAL WAXES

作　　者：李宝才[1] 张惠芬[1] 毕莉[1] 辛晓燕[1] 卜贻孙[2] 

机构地区：[1]昆明理工大学生物与化学工程学院 [2]煤炭科学研究总院环境保护研究所,浙江萧山311201

出　　处：《林产化学与工业》2004年第3期73-77,共5页Chemistry and Industry of Forest Products

基　　金：煤炭科学基金资助项目 (97加 12 72 4 ) ;云南省应用基础基金资助项目 (95E0 5 1M )

摘　　要：对云南潦浒、寻甸及吉林舒兰蒙旦树脂中醇类化学成分进行了GC-MS研究 ,探索蒙旦树脂醇类作为药用资源的可能性。实验结果表明 ,树脂醇由正构烷醇、正构酮 (甲基酮 )、甾醇类、五环三萜醇及五环三萜酮所组成。潦浒、寻甸树脂醇中均存在 2 4 -甲基 - 5 β(H) -胆甾烷 - 3β-醇 (C2 8H50 O ,分子质量 4 0 2 )、2 4 -乙基胆甾 - 5 ,2 2 -二烯 - 3β-醇 (C2 9H48O ,分子质量 4 12 )、2 4 -乙基 - 5α(H) -胆甾烷 - 3β-醇 (C2 9H52 O ,分子质量 4 16 )、2 3,2 4 -二甲基胆甾 - 5 -烯 - 3β-醇 (C2 9H50 O ,分子质量 4 14 )、C2 9- 5 β(H) ,3β(OH) -甾醇 (C2 9H52 O ,分子质量4 16 )、2 4 -异丙基胆甾 - 5 ,2 4 (2 8)E-二烯 - 3β-醇 (C3 0 H50 O ,分子质量 4 2 6 )等甾体类物质。舒兰树脂醇中正构烷醇 ,正构烷酮含量甚低 ,甾醇类几乎没有分布 ,主要是由五环三萜氧化物组成。化学组成表明潦浒。To explore the possibilities of utilizing montan resins as a Chinese medicine,the alcoholic fractions of montan resins isolated from brown coal waxes which were extracted from Liaohu,Xundian(Yunnan) and Shulan(Jilin) brown coals were studied by gas chromatography-spectrometry.The experimental results show that alcoholic fractions in montan resins mainly consist of normal long chain alcohols of carbon number C_(15)-C_(30)(C_(22),C_(24),C_(26) as major constituents for the series),long chain ketones of carbon number C_(18),C_(23),C_(25),C_(27),C_(29) and 15-hentriacotanone,sterols,pentacyclic triterpene alcohols and pentacyclic triterpene ketones.Alcoholic fractions from Xundian and Liaohu contain 24-methyl-5β(H)-cholestane-3β-ol(C_(28)H_(50)O,M_W 402), 24-ethyl-cholest-5,22-dien-3β-ol(C_(29)H_(48)O,M_W 412),24-ethyl-5α(H)-cholestane-3β-ol(C_(29)H_(52)O,M_W 416), 23,24-dimethyl-cholest-5-en-3β-ol(C_(29)H_(50)O,M_W 414),C_(29)-5β(H),3β(OH)-sterol(C_(29)H_(52)O,M_W 416), 24-isopropyl-cholest-5,24(28)E-dien-3β-ol(C_(30)H_(50)O,M_W 426),etc.,at a relatively abundant amount.However sterols are almost absent or in very trace amount in Shulan montan resin.Based on their chemical constituents Xundian and Liaohu brown coal resins would be probably a resource as Chinese medicine.

关 键 词：蒙旦树脂 树脂醇 生物活性物质 药用资源 

分 类 号：TQ351.473[化学工程]