β-胡萝卜素的抗辐射作用  

The Assist Protection by Beta,Carotene Against Gamma Radiation

作　　者：李怡岚[1] 乔珊珊[1] 周蕾[1] 姜淑清[1] 李国星[1] 

机构地区：[1]天津市卫生防病中心毒理室,天津300011

出　　处：《环境与健康杂志》2004年第5期300-302,共3页Journal of Environment and Health

基　　金：天津市自然科学基金资助项目(013613011)

摘　　要：目的研究β-胡萝卜素的抗辐射作用。方法采用30、60、90mg/kgβ-胡萝卜素的剂量对昆明种小鼠进行30d灌胃,然后用4和8Gy的60Co-γ射线照射小鼠,照射后仍给以原剂量灌胃并进行动物平均生存时间、存活率、白细胞计数、骨髓细胞微核、睾丸染色体畸变、免疫功能、组织中超氧化物歧化酶(SOD)活力等的检测。结果各剂量组β-胡萝卜素均能在一定程度上阻止由辐射引起的白细胞下降,提高被辐射小鼠的免疫功能,升高组织中SOD活力,并有抑制微核产生的作用,同时在一定程度上减少由60Co-γ射线而引起的小鼠睾丸染色体畸变,而且可延长动物的生存时间,提高动物的30d存活率。结论β-胡萝卜素具有抗辐射作用。Objective To study the anti,radiation effect of beta,carotene(β,C). Methods The different doses of β,C (30,60 and 90 mg/kg bw) were orally administered separately to three groups of mice, and a control group was also arranged. The four groups of mice were exposed to 60Co,γ rays after 30 days, then all groups were continuously orally administered, the survival rates, survival time, number of white blood cells(WBC), micronucleus frequency(MF), spermatocyte chromosome abberation, immune function, superoxide dismutase(SOD) activity were measured. Results The results showed that compared with control group, groups treated withβ,C expressed lower range WBC decrease, stronger immune function, higher SOD activity, less MF, longer survival time and improved survival rates. Conclusion β,C had radioprotective effect.

关 键 词：Γ射线 Β-胡萝卜素 辐射损伤 拮抗剂 

分 类 号：R994.6[医药卫生—毒理学]