电刺激诱发大鼠慢性颞叶癫痫模型的磁共振成像和波谱特征的研究  

CEREBRAL CHANGES DURING THE EARLY STAGE OF A RAT MODEL OF CHRONIC TEMPORAL EPILEPSY OBSERVED BY MAGNETIC RESONANCE IMAGING AND LOCALIZED IN VIVO 1H MRS

作　　者：杨运煌[1] 臧颖[2] 刁芳明[2] 韩丹[2] 李丽云[1] 叶朝辉[1] 刘买利[1] 

机构地区：[1]波谱与原子分子物理国家重点实验室(中国科学院武汉物理与数学研究所),湖北武汉430071 [2]武汉大学医学院生理学教研室,湖北武汉430071

出　　处：《波谱学杂志》2004年第3期281-288,共8页Chinese Journal of Magnetic Resonance

基　　金：国家自然科学基金(10234070);面上项目(20175035)资助

摘　　要：应用磁共振成像(MRI)和质子定域波谱(1 H-MRS)对强直流电刺激大鼠基树突区诱发慢性颞叶癫痫模型进行研究.MRI实验表明: 随着强直流电刺激时间的延长, 在T2加权像(T2-MRI)中, 模型大鼠的海马区腹、中侧区单侧或双侧, 呈现异常高信号, 扩散加权像(DWI)信号呈低信号, 质子密度像无明显改变, 表明T2值和表观扩散系数(ADC) 值较大的自由水比例增大.磁共振波谱实验发现: 模型大鼠T2-MRI中信号异常区与其对侧区的1 H-MRS相比, NAA, PCr(包括Cr)和 Cho的峰面积均无显著改变, 表明在慢性颞叶癫痫模型早期1 H-MRS不能检测到神经元损伤或死亡.In this study, MRI and localized in vivo ~1H-MRS were applied to study cere- bral changes during the early stage of a rat model of chronic temporal epilepsy. Epilepsy was induced by repetitive tetanus to the right basal dendrite region. Six days after the initial tetanus, T_2 -weighted MRI (T_2W-MRI) revealed that there was a significant in- crease in signal intensity of the right ventral part of hippocampus, the signal intensity of the same region decreased significantly in diffusion-weighted MRI (DWI). Such changes may be caused by the increase of the ratio of free water to bounded water in the affected region. Decrease of NAA was not found in the foci of epilepsy with localized in vivo ~1H- MRS, suggesting that there existed little or no loss of neurons during the early stage of this model of temporal epilepsy.

关 键 词：磁共振成像 颞叶癫痫 定域活体磁共振氢谱 大鼠 波谱特征 

分 类 号：R742.1[医药卫生—神经病学与精神病学] O482.53[医药卫生—临床医学]