C-myc癌基因产物在食管癌中的表达及其意义  

Significance and Overexpression of C-myc Oncoproduct in Esophageal Carcinoma

作　　者：刘复兴[1] 林永生[1] 胡虹[2] 

机构地区：[1]咸宁医学院人体解剖学教研室 [2]咸宁医学院病理学教研室

出　　处：《咸宁医学院学报》1997年第1期12-14,共3页Journal of Xianning Medical College

摘　　要：用免疫组化LSAB方法检测了50例食管鳞癌及癌旁组织中C-myc蛋白的过表达,结果38例癌组织显示强弱不一的阳性反应,阳性反应强度与癌组织分化程度间无显著性相关。癌旁组织仅见2例非典型增生上皮有少数细胞弱阳性。c-myc癌基因激活可能是食管癌变过程中的一个晚期事件。The expression of C-myc oncoprotein in 50 cases of esophageal squamous cell carcinoma (ESCC)and the epithelium adjacent to ESCC was detected by LSAB immunohistochemical technique. 38 of 50 cases revealed a C-myc positive reaction in different degree. There was significant correlation between the grade of positive reaction and the degree of tissue differentiation. Only two cases of the tissue with atypical hyperplasia adjacent ESCC showed lightly C-myc positive staining. The activation of C-myc oncogene might be a delayed accident in the earcinogenesis of the eaophageal epithelium.

关 键 词：C—myc 癌基因 食管癌 表达 

分 类 号：R735.1[医药卫生—肿瘤]