2-苯甲酰基-N-芳基氨基脲的合成及抑菌活性  

Synthesis and Antibacterial Activities of 2-Benzoyl-N-aryl Hydrazinecarboxamides

作　　者：郭佃顺[1] 

机构地区：[1]山东师范大学化学系,济南250014

出　　处：《有机化学》2004年第9期1118-1121,共4页Chinese Journal of Organic Chemistry

基　　金：山东省自然科学基金 (No.Y2 0 0 0B0 5)资助项目

摘　　要：以N 取代三氯乙酰胺在碱催化下与苯甲酰肼反应 ,合成了 8种 2 苯甲酰基 N 芳基氨基脲 3a～ 3h ,其结构经元素分析、IR和1HNMR所表征 ;初步生物活性测定表明 ,部分化合物对大肠杆菌、枯草杆菌和金黄色葡萄球菌具有一定的抑菌活性 .Eight 2-benzoyl-N-arylhydrazinecarboxamides (PhCONHNHCONHAr) (Ar = 2-ClC6H4, 3-ClC6H4, 4-ClC6H4, 3,4-Cl2C6H3, 2-MeC6H4, 3-MeC6H4, 4-MeC6H4, 2,4-Me2C6H3) have been synthesized via the reaction of N-substituted trichloroacetamides with benzoylhydrazine mediated by NaOH and characterized by elemental analyses, H-1 NMR and IR spectra. The biological test shows that some compounds have displayed significant antibacterial activities against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.

关 键 词：2-苯甲酰基-N-芳基氨基脲 合成 抑菌活性 N-取代三氯乙酰胺 苯甲酰肼 

分 类 号：O625[理学—有机化学]