NMR自扩散研究脂肪酸与α-环糊精的相互作用  

NMR Self-diffusion Studies on the Interaction Between α-Cyclodextrin and Fatty Acids

作　　者：徐旻[1] 张惠平[1] 陈群[1] 

机构地区：[1]华东师范大学分析测试中心

出　　处：《高等学校化学学报》2004年第10期1901-1904,共4页Chemical Journal of Chinese Universities

基　　金：教育部优秀青年教师教学与科研奖励基金;上海市纳米专项基金 (批准号 :0 2 5 2 NM0 11)资助

摘　　要：用脉冲梯度场 NMR测量自扩散系数的方法研究了乙酸、丙酸和丁酸与α-环糊精在低于临界浓度条件下的相互作用 .研究发现 ,3种脂肪酸的扩散系数均随着环糊精含量增加而减小 ,其减小趋势与烷基的大小有关 ,烷基越大 ,其扩散系数减小越快 .利用测得的扩散系数计算出 3种脂肪酸和环糊精形成复合物的平衡常数 ,发现平衡常数随烷基链增长而增大 ,该结果与 2 D-ROESY( Rotating Frame Overhauser Effect Spec-troscopy)谱均表明 ,在脂肪酸与α-环糊精相互作用过程中 ,烷基与环糊精内腔的疏水相互作用起主导作用 ,不同脂肪酸和α-环糊精的结合比均为 1∶The association between α-cyclodextrin and three kinds of short chain fatty acids was studied by NMR self-diffusion measurements. Dilute solution condition was adopted to avoid precipitating of the solutes. The diffusion coefficient of fatty acid in the solution, which reflects the strength of association between α-cyclodextrin and fatty acids, was found to decrease with increasing alkyl chain length of fatty acid. Together with 2D-ROESY experiment, therefore, it was demonstrated that in forming inclusion complex, the hydrophobic interaction is predominant among various possible interactions between α-cyclodextrin and fatty acids.

关 键 词：脂肪酸 Α-环糊精 扩散系数 疏水相互作用 平衡常数 NMR自扩散 

分 类 号：O629.2[理学—有机化学] O636.12[理学—化学]