通痹止痛胶囊中挥发油β-环糊精包合物的制备工艺研究  

Study on Preparation of β-cyclodextrin Inclusion Compound of Volatile Oil from Tongbizhitong Capsule

作　　者：赵冬霞[1] 杜瀛琨[2] 

机构地区：[1]河南大学药学院,河南郑州450003 [2]云南中医学院中药系,云南昆明650011

出　　处：《中国中医药信息杂志》2004年第10期885-886,914,共3页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的 确定通痹止痛胶囊中桂枝、苍术、姜黄挥发油β-环糊精的最佳包合工艺条件。方法 以挥发油包合率、包合物收得率为指标,对研磨法、超声法、搅拌法包合挥发油进行了比较试验,并采用正交试验方法,优选超声法制备挥发油-β-环糊精的最佳包合工艺条件。结果 最佳包合工艺条件为:1 mL挥发油加8 g β-环糊精、80 mL水,超声处理45 min。结论 用超声法包合挥发油,包合率较高,生产操作快速、简便,适合于工业化生产。Objective To study optimum inclusion process condition for voltile oil from Tongbizhitong Capsule. Method The study was carried out with camparing three inclusion methods, and then through orthogonal design, the process conditions were optimized by determing the ultizision ratio of volatile oil, the oil-bearing ratio and extract ratio of inclusion compound. Results The optimum preparation condition for inclusions were established as:oil∶β-CD was 1∶8, the amount of water was 80 mL and the time for 45 min. Conclusion The oil-bearing rate is high and the method is applicable.

关 键 词：通痹止痛胶囊 挥发油 Β-环糊精 包合物:制备工艺 

分 类 号：R283.5[医药卫生—中药学]