双水相生物催化技术的研究进展  

Advance in aqueous two-phase biocatalysis system

作　　者：孙广海[1] 周华[1] 朱跃钊[1] 韦萍[1] 

机构地区：[1]南京工业大学制药与生命科学学院,南京210009

出　　处：《生物加工过程》2004年第3期19-22,36,共5页Chinese Journal of Bioprocess Engineering

基　　金：国家自然科学重点基金 ( 2 0 3 3 60 10 )

摘　　要：双水相生物催化是一种高效且易于放大的生物催化技术 ,可以有效解决传统生物催化过程中产物浓度低、产物和副产物的抑制、以及生物催化剂难以回收等缺点。介绍了该技术的操作工艺及设备研究及其在抗生素、激素、肽类和有机化合物酶法合成中的应用研究现状 ,展望了该技术的可能发展方向。Biocatalysis in aqueous two-phase system is an eff ec tive and easy magnified biotechnology, which can solve the defect of low concent ration of products, inhabitation of products or vice products as well as difficu lty in recycling biocatalyst in traditional biocatalysis technique In this art icle, the principle and character of this technique is introduced, and the apply ing situation of this technique in enzymatic synthetic of antibiotics, hormone, peptide, organic compounds is summarized The article also analyzes the effects in engineering magnify in biocatalysis in aqueous two-phase, and predict the g reat potential in biotechnology field

关 键 词：双水相 生物催化 反应分离耦合 工程放大 

分 类 号：Q503[生物学—生物化学]