42例胃癌术中放疗的临床应用研究  

Intraoperative Radiation Therapy for 42 Patients with Gastric Cacinoma

作　　者：王文玲[1] 文小平[1] 赵代炜[2] 王黔[2] 张凤莉[1] 

机构地区：[1]贵阳医学院附属医院肿瘤科,贵州贵阳550004 [2]贵阳医学院附属医院胃肠外科,贵州贵阳550004

出　　处：《肿瘤防治杂志》2003年第12期1294-1295,共2页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :探讨胃癌术中一次性大剂量放疗照射范围、剂量和疗效。方法 :对 4 2例胃癌患者采用12MeV电子线进行术中放射治疗 ,剂量 15～ 2 5Gy ,靶区以瘤床及周围淋巴引流区为主。与 1995年 12月 - 2 0 0 0年 6月单纯手术的 6 0例进行对照。结果 :接受治疗的 4 2例患者中无近远期并发症。Ⅲ期胃癌单纯手术组 3年生存率为 4 8 6 % ,手术加术中放疗组为 72 4 % ,P <0 0 5。Ⅳ期胃癌患者单纯手术组 3年生存率为 2 4 % ,手术加术中放疗组为 2 0 %。结论 :胃癌术中放射治疗不增加术后并发症 ,能提高Ⅲ期胃癌 3生存率。Objective To evaluate the effect,field extent and optimal dose of intraoperative radiation therapy (IORT) in the treatment of gastric carcinoma.Methods Forty-two patients with gastric cancer underwent IORT with 15-25 Gy by 12MeV electron to the tumor and lymphatic regions.Another 60 patients treated by surgery alone during 1996-2000 served as control.Rusults No acute complications were recorded in IORT patients.The 3-year survival rates were not improved in stage Ⅳ diseases,whereas it was increased to 23.8% in the stage Ⅲ patients,when they received surgery combined with IORT.Conclusion Our clinical outcome indicates that combination of surgical resection and IORT is able to improve the survival rate without increasing any complications in the stage Ⅲ gastric cancer.IORT is safe and feasible.

关 键 词：胃肿瘤 放射疗法 胃肿瘤 外科学 综合疗法 病例对照研究 预后 

分 类 号：R735.2[医药卫生—肿瘤]