肝硬化腹水患者治疗前后血浆神经肽Y的变化及意义  

Significances of plasma levels of neuropeptide Y pre-and post-treament in patients with decompensated cirrhosis and ascites

作　　者：李根武[1] 伍灵达[1] 朱艺[2] 

机构地区：[1]广东医学院附属医院消化内科,广东湛江524001 [2]海南省人民医院外科,海南海口570311

出　　处：《第一军医大学学报》2003年第5期483-484,共2页Journal of First Military Medical University

摘　　要：目的研究肝硬化(LC)失代偿期伴腹水患者,以及患者经治疗腹水消退后血浆神经肽Y(NPY)水平的变化,了解NPY与肝功能及腹水的关系。方法放射免疫法检测LC失代偿期伴腹水患者20例的血浆NPY水平,以及腹水消退后血浆NPY水平。结果LC腹水患者血浆NPY水平明显低于正常人(P<0.01);腹水消退后血浆NPY水平较前明显升高(P<0.01),但仍明显低于正常人(P<0.01)。结论LC患者血浆NPY水平的下降与肝功能损害的程度有关,血中NPY的减少可能参与了LC血流动力学的改变及腹水的形成。Objective To observe changes of plasma neuropeptide Y(NPY) lev el in ascitic patients with decompensated cirrhosis pre-and post-treament, there fore to understand the correlation of NPY with liver function and ascitic forma tion. Methods NPY plasma levels in 20 patients with decompensated cirrhosis and ascites were detected by radioimmunological assay. Results Plasma NPY levels in patients with cirrhotic ascites were significantly lower than those in normal s ubjects(P<0.01) in spite of the increases of NPY after ascites decreased (P<0.0 1), which were still lower than those in normal subjects(P<0.01). Conclusion Dec reased plasma NPY levels are correlated with the severity of liver damage and ma y be responsible for the changes of hemodynamics and ascitic formation in patie nts with liver cirrhosis.

关 键 词：肝硬化 血流动力学 腹水 神经肽Y 

分 类 号：R575.2[医药卫生—消化系统]