熊胆消炎胶囊中挥发油β-环糊精包合工艺的研究  

Study on preparation of β-cyclodextrin inclusion complex of volatile oil in Xiongdan Xiaoyan capsules

作　　者：徐雄良[1] 张志荣[1] 何祖兴 黄国庆 冉东 

机构地区：[1]四川大学华西药学院靶向药物与新型给药系统重点实验室,四川成都610041 [2]四川金辉药业有限公司,四川资阳641300

出　　处：《中国中药杂志》2004年第7期644-646,共3页China Journal of Chinese Materia Medica

基　　金：四川省重点科技项目 ( 0 1SG0 0 8 0 1)

摘　　要：目的 :研究β 环糊精包合熊胆消炎胶囊中 3味中药挥发油的制备工艺。方法 :用饱和水溶液法、研磨法、超声法对混合挥发油的包合效果进行比较 ,并用正交试验法对超声法的制备工艺进行研究。结果 :确定了超声法制备包合物的最佳工艺条件。结论 :超声法对混合挥发油的包合率高 ,包合效果佳 ,工艺简便 ,可应用于生产。Objective: To study optimum inclusion conditions for volatile oil from three medicinal slices in Xiongdan Xiaoyan capsules. Method: Saturated water solution method (agitation method), ultrasonic method and rubbing method were studied and compared. The preparation conditions of ultrasonic method were investigated by the orthogonal test. Result: The optimum inclusion conditions of ultrasonic method were established. Conclusion: The ultrasonic method can be used for production of inclusion complex in the factory with high inclusion rate and was effectiveness. [

关 键 词：熊胆消炎胶囊 挥发油 Β-环糊精 制备工艺 正交试验 

分 类 号：TQ461[化学工程—制药化工]