前列腺癌组织中PTEN、E-cadherin蛋白的表达及意义  

Expression of PTEN and E-cadherin in prostate cancer and its significance

作　　者：戚晓平[1] 王金泉[2] 陈清勇[1] 林考兴[1] 李峰[1] 

机构地区：[1]解放军第一一七医院泌尿外科,浙江杭州310013 [2]解放军第一一七医院病理科,浙江杭州310013

出　　处：《现代泌尿外科杂志》2004年第3期128-130,共3页Journal of Modern Urology

基　　金：南京军区医学科研"十五"计划课题 (No .0 2MA0 2 5)

摘　　要：目的　探讨与张力蛋白在 10号染色体同源缺失的磷酸酶 (PTEN)、上皮细胞钙黏素 (E Cad)在前列腺癌组织中的表达及其临床意义。方法　应用免疫组织化学 (SP)方法检测 4 2例前列腺癌、3例正常前列腺组织和 7例良性前列腺增生组织中PTEN、E Cad蛋白的表达。结果　前列腺癌组织中PTEN蛋白表达的阳性率为 2 6 .1% (11/ 4 2 ) ,E Cad蛋白表达的阳性率为 5 0 .0 %(2 1/ 4 2 ) ;随肿瘤细胞病理分级、临床分期程度的增高 ,癌细胞表达PTEN、E Cad蛋白阳性率降低 ,各组间比较差异有显著性 (P<0 .0 1或P <0 .0 5 ) ;正常前列腺组织和良性前列腺增生组PTEN、E Cad蛋白均呈阳性免疫反应。结论　PTEN、E Cad蛋白异常表达在前列腺癌的恶性进展中起重要作用 ,检测PTEN、E Cad蛋白表达有利于判断病期及预后。Objective To investigate the expression of PTEN and E-cadherin (E-Cad) in primary prostate cancer and its clinical significance. Methods PTEN and E-Cad protein expression in paraffin-embedded tissues from 42 prostate cancer samples were analyzed by immunohistochemical staining. Results Cells which showed positive for PTEN, E-Cad were present in 11(26.1%) and in 21(50.0%) primary prostate cancer, the positive coexpression of PTEN and E-Cad was shown in 10 (23.8%) cases. The higher grade and clinical stage the tumor had, the lower expression of PTEN and E-Cad. However, 10 cases with normal and benign lesion were all positive staining. Conclusion The abnormal expression of PTEN and E-Cad might play an important role in primary prostate cancer progression, and examining the two factors might be useful for evaluating disease progression and prognosis.

关 键 词：前列腺癌 肿瘤组织 基因表达 磷酸酶 上皮细胞钙黏素 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]