肿瘤标志物P504S在前列腺癌鉴别诊断中的价值  

Value of P504S in the differential diagnosis of the prostate cancer

作　　者：徐明[1] 周金良[1] 盛惠珍[1] 

机构地区：[1]上海长宁区中心医院病理科,上海200336

出　　处：《诊断学理论与实践》2004年第4期273-276,共4页Journal of Diagnostics Concepts & Practice

摘　　要：目的探讨α鄄甲基酰基辅酶A消旋酶(P504S)在前列腺癌(prostatecancer,PC)和前列腺良性病变中的鉴别诊断意义。方法应用免疫组化EnVision法对105例患者的前列腺疾病进行免疫组化标记。其中PC35例,前列腺良性增生(BPH)50例,非典型腺瘤样增生(AAH)14例和前列腺上皮内高度异形增生(HGPIN)6例。结果P504S在PC、BPH、AAH和HGPIN患者中的阳性率分别为91.4%、0%、21.4%及66.7%;PC患者中P504S的表达明显高于BPH(P<0.01)。结论在前列腺癌鉴别诊断中,P504S能区别良性腺体和癌,P504S与34βE12、P63、CK5/6、PSA联合应用有助于明确诊断穿刺标本中的微量前列腺癌组织。Objective To study the significance of P504S in the differential diagnosis of the prostate cancer(PC). Methods A total of 105 cases, including 35 cases of PC , 50 cases of benign prostatic hypertrophy (BPH), 14 cases of atypical adenomatous hyperplasia (AAH) and 6 cases of high grade prostatic intraepithelial neoplasia(HGPIN), were examined using a panel of antibodies by EnVision immunocytochemical labeling. Results The expressios of P504S in PC, BPH, AAH and HGPIN were 91.43%, 0%, 21.43% and 66.67% respectively, with significant difference between that in PC and that in BPH(P<0.01). Conclusions P504S can be used to differentiate the benign prostate gland from the PC.Combining P504S with 34βE12, P63, CK5/6 and PSA is helpful for the diagnosis of the PC through small amounts of the needle biopsy samples.

关 键 词：肿瘤标志物 前列腺癌 鉴别诊断 甲基酰基辅酶A消旋酶 

分 类 号：R737.25[医药卫生—肿瘤]