抑郁症患者的SPECT局部脑血流研究  

Study on the regional cerebral blood flow in the patients with depressive disorders by ECD/SPECT

作　　者：江旭峰[1] 李培勇[1] 张剑戈[2] 陈刚[1] 于金玲[3] 李彪[1] 朱承谟[1] 

机构地区：[1]上海第二医科大学附属瑞金医院核医学科,上海200025 [2]上海第二医科大学生物医学工程教研室,上海200025 [3]上海市普陀区精神卫生中心,上海200062

出　　处：《诊断学理论与实践》2004年第4期277-279,共3页Journal of Diagnostics Concepts & Practice

摘　　要：目的观察抑郁症患者局部大脑皮层血流灌注异常类型。方法选择未治疗的按CCMD鄄2鄄R标准诊断为抑郁症患者12例,进行脑双半胱乙酯(ECD)显像,并与19名年龄匹配的健康人作比较,用统计参数图(SPM)对图像进行分析。结果SPM分析显示双侧额叶、左侧颞上回、左侧边缘叶钩回(Brodmannarea20)、左侧丘脑乳头体、右侧扣带回、右侧壳核血流下降。结论抑郁症患者额叶、颞叶及边缘系统局部脑血流明显降低。Objective To observe the regional cerebral blood flow (rCBF) abnormalities in the untreated patients with depressive disorders. Methods 99mTc-ECD -brain SPECT imaging was performed in 12 untreated depressive patients diagnosed by CCMD-2-R, who were compared with 19 age-matched normal controls . 99mTc-ECD -brain SPECT data were subjected to SPM. Results SPM showed that the rCBF decreased in the bilateral frontal lobe, the left superior temporal gyrus, the left limbic lobe uncus (Brodmann area 20), the left thalamus mammillary body, the right cingulate and the right putamen. Conclusions The rCBF of the frontal, the temporal and the limbic system decreases dramatically in the patients with depressive disorders.

关 键 词：抑郁症 SPECT检查 脑血流 双半胱乙酯 额叶 颞叶 统计参数图 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R816.1[医药卫生—临床医学]