阿尔茨海默病的免疫治疗  

Amyloid-β immunotherapy for Alzheimer's disease

作　　者：刘春喜[1] 黄耀德[1] 

机构地区：[1]上海第二医科大学基础医学院解剖学教研室,上海200025

出　　处：《上海第二医科大学学报》2004年第8期683-687,共5页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：阿尔茨海默病(AD)是一种最常见的老年期痴呆综合征,其特征性的病理改变之一是β淀粉样蛋白(Aβ)为核心的老年斑。减少Aβ被认为是AD治疗的主要靶向之一,而针对Aβ的免疫疗法也已成为当今AD研究的一大主题。该文就AD免疫疗法的类型、并发症、影响疗效的因素等方面的研究进展作一综述。Alzheimer's disease (AD) is the most common form of dementia among the elderly. Plaques containing β-amyloid ( Aβ) protein are one of the pathological features of AD, and the reduction of Aβ is considered as a prima-ry therapeutic target. Aβ immunotherapy is an evolving approach to the treatment of Alzheimer's disease now. In this article, we will review active and passive immunization against Aβ and the studies related to AD immunotherapy.

关 键 词：阿尔茨海默病 免疫治疗 AD 老年期 痴呆综合征 Β淀粉样蛋白 AΒ 

分 类 号：R749.16[医药卫生—神经病学与精神病学]