手术前后结肠癌患者的血清NO变化及临床意义  

The variations in serum levels of nitric oxide(NO) in patients with colon oxide cancer and its clinical significance during operation

作　　者：沈雁[1] 关广雄[2] 陈志棠[1] 陈涛[3] 钟灿灿[1] 

机构地区：[1]广州市红十字会医院创伤外科研究所,510220 [2]广州医学院第二附属医院检验科,510260 [3]广州医学院第一附属医院检验科,510120

出　　处：《广州医药》2004年第5期61-63,共3页Guangzhou Medical Journal

摘　　要：目的　研究一氧化氮 (NO)在结肠癌患者手术前后血清中的浓度变化及其临床意义 ,探讨在结肠癌肿瘤免疫方面的作用。方法　采用硝酸还原法测定 31健康人和 4 3例结肠癌患者血清NO水平。结果　结肠癌患者术前血清NO含量 (116± 10 5 ) μmol/L显著高于健康人 (5 1 4 3± 16 2 ) μmol/L ,两者比较为P <0 0 5 ,结肠癌者术后 3天的血清NO含量为 (6 8 1± 5 4 3) μmol/L ,与术前组相比明显降低 (P <0 0 5 ) ,但术后 7天 (10 9 2± 79 8) μmol/L上升到接近术前水平 (P >0 0 5 ) ,有淋巴结转移组 (87 0± 6 5 8) μmol/L ,低于无淋巴结转移组 (10 8 9± 6 8) μmol/L(P <0 0 5 )。结论　NO可能在分子水平参与结肠癌的发生和发展。Objective To study the variations in serum levels of nitric oxide (NO) in preoperative and postoperative patients with colon cancer and its clinical significance and to explore its function in colon tumor immunization. Methods The methods of nitrifying ferment was used to test the serum level of NO from 31 healthy persons and 43 patients with the colon cancer. Results The serum level of NO was higher in preoperative patients[(116±105)μmol/L] than that in the healthy persons [(51.43±16.2)μmol/L]. In comparison the significant level is at P<0.05. The serum level of NO[(68.1±54.3)μmol/L] was lower in the colon cancer patient 3 days after the operation than that in the preoperative group (P<0.05), but the serum level [(109.2±79.8)μmol/L]increased 7 days after the operation to the approximate preoperative level(P>0.05). The serum level of NO in the lymphnode metastasis group was lower[(87.0±65.8)μmol/L]than that in the mon-metastasis group[(108.9±68)μmol/L] (P<0.05). Conclusion NO may play an important role at molecular level during the course of colon cancer development.

关 键 词：手术 结肠癌 一氧化氮 血清NO 肿瘤 

分 类 号：R735.35[医药卫生—肿瘤]