二氧化硅对肺泡巨噬细胞的毒性作用  

TOXIC EFFECT OF SILICA ON ALVEOLAR MACROPHAGE

作　　者：杨震[1] 陈荣三[1] 毛延[1] 戴安邦[1] 

机构地区：[1]南京大学配位化学研究所

出　　处：《南京大学学报（自然科学版）》1989年第1期48-56,共9页Journal of Nanjing University（Natural Science）

基　　金：国家自然科学基金

摘　　要：测定了鳞石英、α—这石英和硅胶以及它们和卵磷脂作用的表面(电位,研究了它们对家兔肺泡巨噬细胞的毒性作用。结果表明:二氧化硅的表面)电位越高,与卵磷脂等肺表面活性物质作用越强,因而致硅肺作用越强烈。毒性作用顺序为:鳞石英>α—石英>硅胶。The ζ electric potentials of tridymite, α—quartz and silica gel before and after being reacted with lecithin have been determined.The toxic effect of these species on rabbit alveolar macrophage was studied and the result showed that the higher the ζ electric potential of silica species, the stronger the reaction with lecithin and the more toxic its silicotic effect. The order of toxicity is found to be, tridymite >α——quartz>silica gel.

关 键 词：鳞石英 肺泡 巨噬细胞 卵磷脂 毒性 

分 类 号：R135.2[医药卫生—劳动卫生]