大块状生物活性玻璃陶瓷表面复合骨髓-骨松质的成骨作用研究  

The Study of Capacity of ABMC Osteogensis on Surfaceof Block Bioactive Glass Ceramic

作　　者：王慧明[1] 王模堂[2] 林军[1] 吴求亮[1] 

机构地区：[1]浙江医科大学附属第一医院,310003 [2]华西医科大学口腔医学院,610041

出　　处：《中国口腔种植学杂志》1998年第4期161-164,186,共5页Chinese Journal of Oral Implantology

摘　　要：将自体骨髓 -骨松质 (ABMC)复合于块状生物活性玻璃陶瓷 (BGC)表面 ,植入12条杂种狗无骨膜的下颌骨缺损区 ,分别于术后4周、12周、20周和40周处死 ,采用光镜、荧光显微镜及扫描电镜观察局部新骨生成与改建状况。发现术后4周时植入BGC上面有多量的新生骨形成 ,随时间的推移 ,此层骨组织增厚 ,并从不规则的骨芽向小梁骨转化 ,沉积在BGC表面或微孔内。而对照组始终末见骨形成。此结果表明BGC可以作为ABMC的生物载体 ,促进ABMC的异位成骨效应。BGC表面复合ABMC种植改善了BGC的力学强度 。Block bioactive glass ceramics on surfaces with autogenous marrow were implanted in the mandibular defects around which the periosteum were removed,16 dogs were sacrificed at 4,12, 20 and 40 postimplantation. LM, FLM and SEM were used for observation.At the fourth week histological observation revealed appear new bone in the region of interface with partial resorption of cancellous bone.By time passed new bone increased and became regular arranged structure. At last these bone disposed on surface of BGC or infiltrated the pores and directly bone bonding was showeed. The results indicated that BGC can be used as biological carrier for ABMC and promoted the osteogenis of it. This method also could increase the strength of artificial bone.

关 键 词：大块状生物活性玻璃陶瓷 表面 骨髓-骨松质 成骨作用 

分 类 号：R783.1[医药卫生—口腔医学]