β-环糊精用于盐酸金刚烷胺的示波极谱测定  

USE OF β-CYCLODEXTRIN IN THE OSCILLOPOLAROGRAPHIC DETERMINATION OF AMANTADINE

作　　者：倪宏刚[1] 郑建斌[1] 

机构地区：[1]西北大学分析科学研究所,西安710069

出　　处：《理化检验（化学分册）》2004年第10期574-576,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：国家自然科学基金资助项目(20275030)教育部科学技术研究重点项目(02187)教育部高等学校骨干教师资助计划(GC-150-71006-2877)陕西省教育厅专项基金项目(01JK076)

摘　　要：在0.2mol·L-1NaOH底液中,β-环糊精能够产生灵敏切口,其深度随盐酸金刚烷胺-β-环糊精包结物量的增加而变浅。根据β-环糊精的示波特性,建立了用二次微分简易示波伏安法间接测定片剂中盐酸金刚烷胺含量的新方法。盐酸金刚烷胺的浓度在1.0×10-6-3.6×10-5mol·L-1范围内呈线性,回归方程h(V)=97.66+7.27×105c(mol·L-1),相关系数为0.995 6,检出限为4.0×10-7mol·L-1。对于2.5×10-5mol·L-1盐酸金刚烷胺钠5次测定的RSD为3.1％。与其他方法相比,此法具有仪器简单、快速、无需通氮除氧等特点。In a base solution of 0. 2mol · L -1 NaOH, a sensitive incision was observed in the dE/dt-E curve of oscillopolarogram of β-cyclodextrin (β-CD) at -0. 45V(vs. SCE). The depth of the incision or the peak hieght of its 2nd derivative oscillopolarogram was found to diminish in the presence of amantadine, due to the formation of an inclusion complex between β-CD and amantadine. Thus, the 2nd derivative oscillopolarography was proposed as an indirect method for the determination of amantadine. Under the optimum condition, linear relationship was obtained between the peak height (V) of the 2nd derivative oscillopolarogram and the concentration of amantadine (mol · L-1) in the range of 1.0×10-6-3. 6×10-5mol · L-1, with a detection limit of 4. 0×10-7mol · L-1. RSD's (n= 5) found at the concentration level of 2. 5×10-5mol· L-1 was 3. 1%.

关 键 词：示波分析 示波测定 Β-环糊精 盐酸金刚烷胺 

分 类 号：O657.1[理学—分析化学]