抽动秽语综合征伴或不伴ADHD的P300波形和脑地形图对照研究  

Study of the character of auditory P300 of Tourette’s syndrome with or without attention deficiency and hyperactivity disorder.

作　　者：朱焱[1] 苏林雁[1] 吴大兴[1] 姚树桥[1] 周明[1] 李飞[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,湖南长沙410011

出　　处：《中国儿童保健杂志》2004年第5期369-372,共4页Chinese Journal of Child Health Care

基　　金：国家自然科技基金 (30 30 0 1 1 8)

摘　　要：【目的】　探讨抽动秽语综合征 (Tourette’ssyndrome ,TS)伴与不伴注意缺陷多动障碍 (attentiondefi ciencyandhyperactivitydisorder ,ADHD)的听觉P3 0 0波形和脑地形图的特征。 　【方法】　以听觉靶和非靶刺激为诱发事件 ,检测单纯TS组 ( 19例 )、TS +ADHD组 ( 15例 )、对照组 ( 2 0例 )儿童在前额区 (Fz)、中央区 (Cz)、顶区 (Pz)、左中央区 (C3 )、右中央区 (C4) 5个点的听觉P3 0 0潜伏期、波幅、波形、脑地形图并进行对比研究。　【结果】　①TS组(Cz ,Pz点 )和TS +ADHD组 (Pz点 )的听觉P3 0 0潜伏期比对照组延长 ,两组Cz、C3 、C4、Pz点的波幅均比对照组低 ,以上差异均有显著性 (P <0 .0 5 ) ;②单纯TS组和TS +ADHD组的P3 0 0潜伏期和波幅之间比较 ,差异无显著性 ;③TS+ADHD组P3 0 0出现异常波形、不对称性扩散和最高电位区异常分布的发生率均高于单纯TS组和对照组 (P <0 .0 5 ) ;④对各组的P3 0 0脑电地形图进行叠加显示 :对照组P3 0 0扩散呈同心圆状 ,左右对称 ;单纯TS组电位右偏 ,TS +ADHD组电位左偏。　【结论】　TS伴与不伴ADHD的皮层认知功能均有损害 ,两者的P3 0Objective To investigate the character of auditory P300 of Tourette’s syndrome(TS) with or without attention deficiency and hyperactivity disorder (ADHD). There were 19 TS children,15 TS+ADHD children and 20 normal controls who were recorded and compared by P300 in Fz,Cz, C 3, C 4 and Pz. TS group (Cz,Pz)and TS+ADHD group(Pz)showed later latencies and decreased amplitudes (Cz, C 3, C 4, Pz) than normal group(P<0.05). No group differences of latencies and amplitudes were found between TS and TS+ADHD groups;The prevalence of abnormal P300 form,lateralized and topography of P300 peak in TS+ADHD group were significant more than those in TS and normal groups(P<0.05);The topography of P300 in TS group showed right lateralized,it was left lateralized in TS+ADHD group. [Conclusion] The findings suggest that TS with and without ADHD all have cognitive function deficit, there are some P300 differences between TS with or without ADHD.

关 键 词：抽动秽语综合征 注意缺陷多动障碍 诱发电位 听觉 

分 类 号：R749.94[医药卫生—神经病学与精神病学]