帕金森病大鼠中缝背核5-羟色胺能神经元放电频率和放电形式的变化  

Changes of discharge rate and pattern of 5-hydroxytrypamine neurons of dorsal raphe nucleus in a rat model of Parkinson’s disease

作　　者：褚玉霞[1] 刘健[1] 冯洁[1] 王勇[2] 张巧俊[2] 李强[1] 

机构地区：[1]西安交通大学医学院生理学教研室,西安710061 [2]西安交通大学第二医院神经内23科,西安710004

出　　处：《生理学报》2004年第5期597-602,共6页Acta Physiologica Sinica

基　　金：This work was supported by the National Natural Science Foundation of China (No. 30370464) and the Natural Science Foundationof Shaanxi Province (No. 2003C216).

摘　　要：实验采用玻璃微电极细胞外记录法, 观察了帕金森病(Parkinson’s disease, PD)大鼠中缝背核(dorsal raphe nucleus, DRN)5- 羟色胺(5-hydroxytrypamine, 5-HT)能神经元电活动的变化。结果发现, 对照组和 PD 组大鼠 DRN 中 5-HT 能神经元的放电频率分别为(1.61 ±0.56) Hz 和(2.61 ±1.97) Hz, PD 组大鼠的放电频率显著高于对照组(P<0.05)。在对照组大鼠, 79% 的神经元呈现规则放电, 21% 为爆发式放电;在 PD 组大鼠,具有规则、不规则和爆发式放电的神经元比例分别为 36%、16% 和47%, 爆发式放电的 5-HT 能神经元比例明显高于对照组(P<0.05)。结果表明,帕金森病大鼠 DRN 中 5-HT 能神经元的放电频率增高, 且爆发式放电增多。In the present study, changes of the neuronal activity of 5-hydroxytrypamine (5-HT) neurons of dorsal raphe nucleus(DRN) in a rat model of Parkinson’s disease(PD) were investigated with glass microelectrode recording. The results showed that the discharge rates of 5-HT neurons in control and PD rats were (1.61 ± 0.56) Hz and (2.61 ± 1.97) Hz, respectively. The discharge rate of PD rats was significantly increased when compared to that of the control rats. In control rats, 79% of 5-HT neurons discharged regularly and 21% in bursts. In PD rats, however, 36% of 5-HT neurons discharged regularly, 16% irregularly and 47% in bursts. The percentage of 5-HT neurons discharging in bursts was obviously higher than that of the control rats (P<0.05). The data suggest that the discharge rate and bursting pattern of 5-HT neurons in DRN are increased in a rat model of Parkinson’s disease.

关 键 词：帕金森病 中缝背核 5-羟色胺 6-羟多巴胺 电生理学 大鼠 

分 类 号：R742.5[医药卫生—神经病学与精神病学]