腮腺幼年型血管瘤中bFGF表达及肥大细胞计数的研究  

The study on expression of bFGF and quantity of mast cell in infant hemangiomas of grandulae parotid gland

作　　者：林晓萍[1] 刘维贤[1] 李吉[1] 

机构地区：[1]中国医科大学第二医院口腔科,辽宁沈阳110004

出　　处：《上海口腔医学》2004年第3期167-167,172,178,共3页Shanghai Journal of Stomatology

摘　　要：本研究采用特殊肥大细胞染色法、免疫组化法及图像分析技术,对40例婴幼儿腮腺血管瘤、5例正常腮腺组织进行肥大细胞和bFGF的定性和定量检测。结果显示:腮腺幼年型血管瘤中肥大细胞的数量、面积及平均光密度均明显增加,差异显著;腺小叶内及幼稚毛细血管中出现大量的肥大细胞;血管瘤组bFGF呈高表达,bFGF阳性物质主要存在于细胞的胞浆,主要分布于细胞外基质,呈浅网状。本研究表明:bFGF和肥大细胞与腮腺幼年型血管瘤的发生具有非常密切的关系。The qualitative and quantitative study on mast cells and bFGF in 40 cases of infant hemangiomas of the grandulae parotid and 5 cases of normal grandulae parotid tissues were investigated by special mast cell staining methods, immunohistochemistry and image analysis technique. The quantity, area and average density of MC remarkably increased, there were significant differences. The mast cells mainly distributed around premature blood vessels and in parotid gland leaves; bFGF was highly expressed in infant hemangiomas of grandulae parotid. Its immuno- reactivity was present in the cytoplasm of endotheliocytes,mainly in extracellular matrix, distributed in light reticulation. It is concluded that there was a close relationship between bFGF and mast cell in proliferation of infant hemangiomas of grandulae parotid.

关 键 词：碱性成纤维细胞生长因子 肥大细胞 肝素 血管瘤 

分 类 号：R739.8[医药卫生—肿瘤]