新鲜羊膜移植治疗眼表疾病的临床观察  

Fresh amnion in treating ocular surface disease

作　　者：王正华[1] 张晓琳 

机构地区：[1]中国茂名市人民医院眼科,525000 [2]中国广州市海珠区第一人民医院眼科,510220

出　　处：《国际眼科杂志》2004年第4期762-764,共3页International Eye Science

摘　　要：目的:探讨新鲜羊膜移植治疗眼表疾病的可行性并对其疗效进行评价。方法:选择本院就诊的翼状胬肉40例(50眼),广泛睑球粘连2例(4眼),急性碱烧伤5例(9眼)、结膜乳头状瘤3例(6眼)共50例(69眼)。分别进行羊膜移植术。术后观察视力、裂隙灯检查角膜上皮修复情况,羊膜成活情况及新生血管长入情况。随访观察3～24mo。结果:69眼均未发生新鲜羊膜植片的急性排斥反应和感染现象。急性严重碱烧伤5例抢救成功。视力有不同程度提高。睑球粘连2例(4眼)恢复了眼球运动并提高了视力。40例(50眼)翼状胬肉有4眼复发,复发率为8%,与其它2种术式相比本法复发率较低。结论:新鲜羊膜移植治疗翼状胬肉能有效地降低复发率。治疗化学伤能减轻炎症、减少新生血管形成,减少并发症,为眼表重建提供了一种有效的生物材料。AIM: to explore the feasibility and effect of treating ocular surface disease with fresh amnion. · MOETHODS: Fifty cases (69 eyes) of ocular surface diseases, including 40 case s (50 eyes) of pterygium, 2 cases (4 eyes) of extensive symblepharon, 5 cases (9 eyes) of acute alkali burn and 3 cases (6 eyes) of papilloma of conjunctiva, un derwent amnion transplantation. Visual acuity, corneal epithelial rehabilitation under slit lamp, amnion and neovascular growth were observed during the follow- up of 3-24mo. · RESULTS: No acute rejection or infection occurred in all the cases. The 5 cas es of acute alkali burn were successfully salved and their visual acuities were improved to various degrees. Ocular movements were regained in the 2 cases of to tal symblepharon, and their visual acuities were improved too. Among the 40 cas es of pterygium, recurrence appeared in 4 cases (8%), with the lowest recurrent rate compared with another two methods. · CONCLUSION: Using fresh amnion in treating ocular surface disease can lower t he recurrent rate, inhibit inflection, and reduce neovascularization and complic ations, thus offers an effective biological material for ocular surface reconstr uction. ·

关 键 词：新鲜羊膜移植 治疗 眼表疾病 临床观察 

分 类 号：R779.6[医药卫生—眼科]