口腔黏膜良性淋巴组织增生病的免疫组化研究  

Immunohistochemical study of benign lymphoadenosis of oral mucosa

作　　者：李曙霞[1] 于世凤[1] 孙开华[1] 

机构地区：[1]北京大学口腔医学院病理研究室,100081

出　　处：《中华口腔医学杂志》2004年第5期410-413,共4页Chinese Journal of Stomatology

摘　　要：目的　研究口腔黏膜良性淋巴组织增生病与口腔癌的细胞增殖能力、血管密度和细胞凋亡的变化。方法　采用免疫组化SP法检测 15例黏膜良性淋巴组织增生病、9例黏膜良性淋巴组织增生病伴上皮异常增生、15例口腔癌及 10例正常黏膜组织中Ki 6 7的表达、细胞凋亡及微血管密度。结果　口腔黏膜良性淋巴组织增生病伴异常增生及鳞状细胞癌中Ki 6 7的表达明显高于不伴异常增生的口腔黏膜良性淋巴组织增生病及正常黏膜 (P <0 0 5 ) ,在所有的口腔黏膜良性淋巴组织增生病及鳞状细胞癌中微血管密度均明显高于正常组 (P <0 0 5 )。口腔黏膜良性淋巴组织增生病中细胞凋亡明显高于正常黏膜及口腔癌 (P <0 0 5 )。结论　在伴有上皮异常增生的口腔黏膜良性淋巴组织增生病中Ki 6 7表达及微血管密度均介于正常组织和口腔癌之间 ,凋亡细胞数也明显多于正常组织。研究结果提示Objective To study the expression of Ki 67 and the changes of MVD and apoptosis in benign lymphoadenosis of oral mucosa(BLOM). Methods The expression of Ki 67, CD34 and apoptosis were evaluated by SP immunohistochemical staining in 15 BLOM, 9 BLOM with dysplasia, 15 oral squamous cell carcinoma (OSCC). Results The expression of Ki 67 in BOLM with dysplasia and OSCC was significantly higher than that of BLOM without dysplasia and normal oral mucosa ( P <0 05).The MVD in all BLOM and OSCC was significantly higher than that in normal mucosa ( P <0 05). Apoptosis in BLOM was higher than in normal mucosa and OSCC ( P <0 05). Conclusions The expression of Ki 67 and MVD in BLOM with dysplasia were between normal oral mucosa and oral carcinmona. The occurrence of apoptosis in BLOM was significantly higher than in normal oral mucosa. The results suggest that BLOM had the potentiality of malignant transformation.

关 键 词：口腔黏膜良性淋巴组织增生病 免疫组化 细胞增殖能力 血管密度 细胞凋亡 

分 类 号：R781.5[医药卫生—口腔医学]