胶原基纳米骨修复拔牙创及颌骨囊肿术后骨腔的疗效观察  

Observation of curative effects of collagen based composite (nHAC) in repairing dental extraction wounds and the cavum after the operations of cyst of jaw

作　　者：廖福琴[1] 张洁[1] 吴燕丽[1] 韩志峰[1] 张丽军[1] 朱菲[1] 姚丽[1] 张昊[1] 齐小良[1] 胡雪兰[1] 崔福斋[2] 

机构地区：[1]北京市和平里医院口腔科,100013 [2]清华大学材料科学与工程系

出　　处：《中国骨质疏松杂志》2004年第3期316-318,329,共4页Chinese Journal of Osteoporosis

基　　金：首都医学发展科研基金资助项目 (首都TS1998ll)

摘　　要：目的　研究胶原基纳米骨 (nHAC)修复智齿拔牙创及颌骨囊肿术后骨腔的治疗效果。方法　 6 6例患者按照自愿原则分为 3组 :nHAC组 30例 ,阻生齿 2 1例 ,根端囊肿 9例 ,骨创植入nHAC ;多孔矿化骨 (Bio Oss)组 6例 ,阻生齿 2例 ,根端囊肿 3例 ,含牙囊肿 1例 ,骨创植入Bio Oss;对照组 30例 ,阻生齿 2 7例 ,根端囊肿 3例 ,骨创不植入材料。结果　nHAC与Bio Oss组 ,12周时x线显示两者骨密度基本一致。nHAC与空白对照组临床疗效差异有显著性。结论　nHAC生物相容性好 ,是一种较为理想的骨替代材料 ,可以在临床推广应用。Objective To study the curative effects of collagen based composite (nHAC) in repairing the wounds after wisdom tooth extraction and the cavum after the operations of cyst of jaw. Methods 66 patients are divided in 3 groups: nHAC group, 30 patients including 21 of impacted tooth and 9 of periapical cyst, in which nHAC were put into the bone wounds; Bio-Oss group, 6 patients including 2 of impacted tooth, 3 of periaPical cyst and 1 of dentigerous cyst, in which Bio-Oss were put into the bone wounds; Contrasting group, 30 patients including 27 of impacted tooth and 9 of periapical cyst, in which no material was put into bone wounds. Results At 12 weeks, there are no significant differences of the bone density with X-ray photo between the nHAC group and Bio-Oss/group; and there are obvious differences of curative effects between the nHAC group and contrasting group. Conclusion nHAC, with its sound biocompatibility, can be considered as an ideal alternative for bone replacement and be extended to and applied in more clinic works.

关 键 词：HAC Bio-Oss 拔牙创 骨腔 纳米骨 颌骨囊肿 阻生齿 胶原 术后 骨修复 

分 类 号：R782[医药卫生—口腔医学] R318[医药卫生—临床医学]