CT灌注成像在肾癌预后评估方面的应用价值  

CT perfusion imaging in evaluating renal carcinoma

作　　者：袁庆中[1] 田建明[1] 王培军[1] 邵成伟[1] 李树平[1] 李跃华[1] 任方远[1] 

机构地区：[1]上海市长海医院放射科,上海200433

出　　处：《中国医学影像技术》2004年第9期1403-1405,共3页Chinese Journal of Medical Imaging Technology

摘　　要：目的　探讨CT灌注成像在评估肾癌预后和术式选择等方面的应用价值。方法　 2 0例肾癌患者 ,根据临床分期分成局限组和转移组 ;根据病理分级分成低度活性组和中高度活性组 ,及健康自愿者 3 0人进行肾区CT平描 ,之后选择经肾门或肿瘤的最大层面进行动态增强扫描 ,应用感兴趣区域分析法 ,计算正常肾皮质和肾癌组织的灌注值。结果　转移组肾癌灌注值显著高于局限组 (t检验 ,P =0 .0 15 ) ,中高度活性组肾癌灌注值亦显著高于低度活性组 (t检验 ,P =0 .0 14 )。结论　CT灌注成像在评估肾癌预后和术式选择等方面具有一定的临床应用价值。Objective To discuss the value of CT perfusion imaging in evaluating renal cell carcinoma (RCC). Methods CT perfusion was performed in 30 healthy subjects and 20 cases of RCC to obtain the time-density curves of nomal renal cortex and RCC. A single slice through the renal hili or tumor was scanned after the intravenous injection of 40～50 ml of contrast given at 5ml/s. Thirty scans were performed from 8 to 37s after injection at 0.5 s duration and 0.5 s interval. Time-density curves were then drawn for both kidneys or renal tumor and aorta using regions of interest (ROIs). Perfusion was calculated as the peak upslope of the tissue time-density curve divided by peak aortic enhancement. All 20 cases of RCC were divided into two groups based on clinical stages: local group (12 cases) and metastatic group (8 cases), and were divided into two other groups based on pathological stages: low grade group (11 cases) and middle or high grade group (9 cases). Results Renal cortical perfusion of healthy subjects was (2.68±0.40) ml/(min·ml), and perfusion of RCC was (1.51± 0.68 ) ml/(min·ml). Perfusion of metastatic group was significantly higher than that of local group ( t test, P =0.015 ), and perfusion of middle or high grade group was also significantly higher than that of low grade group ( t test, P =0.014). Conclusion CT perfusion imaging is valueable in evaluating RCC.

关 键 词：体层摄影术 X线计算机 灌注 肾 肾癌 

分 类 号：R814.42[医药卫生—影像医学与核医学] R737.11[医药卫生—放射医学]