乳腺癌p53和c-erbB-2基因表达与腋淋巴结转移的相关性分析  

Relation between axillary node metastasis and the expression of c-erbB-2 and p53 in breast cancer

作　　者：罗开[1] 于泽平[1] 王震龙[1] 王卫红[1] 石群立[2] 黎介寿[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所 [2]南京军区南京总医院病理科,江苏南京210002

出　　处：《医学研究生学报》2004年第10期884-886,共3页Journal of Medical Postgraduates

摘　　要：目的 :通过免疫组化方法检测乳腺癌患者 p5 3和c erbB 2基因表达 ,分析其与腋淋巴结转移的相关性。 方法 :乳腺癌患者 6 7例 ,均行改良根治术。标本常规石蜡包埋切片 ,苏木精 伊红 (H E)染色 ,计算淋巴结总数和阳性淋巴结数 ;同时取乳腺癌组织石蜡切片行c erbB 2和 p5 3免疫组化染色 ,阳性判断按癌细胞染色细胞的百分率计算 ,不染色为阴性 ;<2 5 %为 (+) ;2 5 %～ 5 0 %为 (2 +) ;>5 0 %为 (3+)。　结果 :所有患者均经常规病理证实为乳腺导管癌 ,淋巴结转移阴性者 31例 ,占 4 6 % ,阳性者 36例 ,占 5 4 %。 p5 3阳性者占 5 6 % ,淋巴结转移阳性者p5 3阳性率低于阴性者 ,但差异无显著性意义。淋巴结转移阳性者c erbB 2阳性率高于阴性者 ,但差异无显著性意义。p5 3和c erbB 2同时阳性者有淋巴结转移者例数明显多于两者同时阴性及单独阳性者 (P <0 .0 5 )。　结论 :p5 3和c erbB 2在乳腺癌患者有比较高的阳性表达 ,两者单独阳性与腋淋巴结转移相关性无显著性意义 。Objective:To study the relation between axillary node metastasis and the expression of c-erbB-2 and p53. Methods:Among 67 breast cancer (NNBC) patients with the modify radical mastectmoy, c-erbB-2 and p53 oncogenes were identified prospectively using immunohistochemical staining. The axillary node metastasis was examined. Furthermore, the possible relation between axillary node metastasis and the expression of c-erbB-2 and p53 were investigated. Results:The prevalence rates for staining of p53 were 56.4%. By univariate analysis, the expressions of c-erbB-2 and p53 were associated significantly in patients with the axillary node metastasis. Conclusion:The simultaneously expressions of c-erbB-2 and p53 appear to be the strong marker for predicting the axillary node metastasis.

关 键 词：乳腺癌 P53 c—erbB-2 腋淋巴结转移 

分 类 号：R737.9[医药卫生—肿瘤]