CA19-9及其同分异构体CD15s在大肠癌表达的对比研究  

Expression of CA19-9 and its isomer CD15s antigen in colorectal carcinoma and their relationships with malignant proclivity

作　　者：尚培中[1] 谷化平[2] 

机构地区：[1]解放军第251医院普通外科,河北张家口075000 [2]解放军第251医院病理科,河北张家口075000

出　　处：《中国现代普通外科进展》2004年第5期289-291,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的 :探讨CA19 9及其同分异构体CD15s在大肠癌中的表达及其与肿瘤发生、分化、转移及预后的关系。方法 :应用催化信号放大法 (CSA)检测 15 0例大肠癌、84例转移淋巴结和 5 0例远离癌组织的正常大肠黏膜CA19 9及其同分异构体CD15s的表达状况。结果 :CA19 9和CD15s阳性物质在远离癌组织的正常大肠黏膜中阳性表达率分别为 88.0 % (4 4 / 5 0 )和 18.0 % (9/ 5 0 ) ,在大肠癌组织中阳性率分别为 81.3% (12 2 / 15 0 )和 94 .0 % (14 1/ 15 0 ) ,转移淋巴结标本中阳性率分别为 6 6 .7% (5 6 / 84 )和 95 .2 % (80 / 84 )。结论 :作为预测大肠癌侵袭、转移及评估患者预后的肿瘤相关抗原 ,CD15s比CA19Objective:To investigate the level of cell adhesion molecule CA19-9 and its isomer CD15s antigen expression in colorectal carcinoma and their relationships with carcinogenesis,differentiation,metastasis and prognosis.Methods:The expression of CA19-9 and CD15s antigen were studied by immunohistochemistry with catalyzed signal amplification(CSA) method in 150 carcinomas and 50 normal mucosal specimens of colon and rectum,as well as in 84 metastatic lymph nodes.Results:The expression frequency rate of CA19-9 and CD15s antigen in normal mucosa distant from carcinoma lesions were 88.0%(44/50) and 18.0%(9/50),whereas in carcinomas were 81.3%(122/150) and 94.0%(141/150).In metastatic lesion of lymphnode CA19-9 and CD15s antigen were expressed as 66.7% (56/84) and 95.2%(80/84) respectively.Conclusion:These suggest that CD15s antigen may be more important than CA19-9 to be used for estimating infiltration,metastasis and prognosis as a tumor-associated antigen in colorectal carcinoma.

关 键 词：结肠直肠肿瘤 CA19-9抗原 抗原 CD15 

分 类 号：R735.34[医药卫生—肿瘤]