非侵入性脑内给药  

Non-invasive drug delivery into brain

作　　者：吴少平[1] 孙曼霁[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《生命科学》2004年第5期292-295,共4页Chinese Bulletin of Life Sciences

摘　　要：血脑屏障使许多具有中枢神经活性的药物无法到达脑部发挥作用,非侵入性脑内给药因对机体无创伤而受到研究者广泛关注。本文介绍了血脑屏障的物质转运系统以及经鼻粘膜、渗透性血脑屏障开放、纳米粒载体和转运载体法等非侵入性脑内给药方法的机制和特点。The blood-brain barrier (BBB) restricts the transport action and action of many central neuroactivedrugs in the brain.Thus the non-invasive drug delivery to brain has been following with great interest. In thispaper, the mechanism and characteristics of the non-invasive drug delivery through nasal mucosa, osmoticopening of the BBB, nanoparticulate and transporter vectors is introduced and discussed.

关 键 词：血脑屏障 药物转运 非侵入性 

分 类 号：R743[医药卫生—神经病学与精神病学] R452[医药卫生—临床医学]