血管内皮生长因子、p53在卵巢上皮癌中表达的临床意义  

SIGNIFICANCE OF VEGF, p53 PROTEIN EXPRESSION IN EPITHELIAL OVARIAN CANCER

作　　者：孙立新[1] 武燕[1] 连润生[2] 韩海琼[1] 王全红[3] 焦士兰[3] 

机构地区：[1]山西省肿瘤医院妇科,山西太原030013 [2]山西省肿瘤医院急诊科,山西太原030013 [3]山西省肿瘤医院病理科,山西太原030013

出　　处：《肿瘤研究与临床》2004年第5期306-308,共3页Cancer Research and Clinic

摘　　要：目的:探讨血管内皮生长因子(VEGF)和癌基因p53在卵巢上皮癌表达的相关性及其与卵巢上皮癌临床病理因素的关系以及对卵巢癌患者预后的影响。方法:用免疫组化二步法检测73例卵巢上皮肿瘤组织中VEGF、p53蛋白的表达(良性上皮瘤24例,交界性上皮瘤7例,上皮性癌42例)。结果:VEGF在卵巢上皮肿瘤组织中的表达,恶性组阳性表达率(86.36 %)明显高于交界性组(66.67 %)及良性组(37.50 %)(P<0.005);在恶性组中,VEGF表达在不同的病理分级、临床分期中无明显差异(P>0.05)。p53在卵巢上皮肿瘤组织中的表达,恶性组阳性表达率(76.19 %)明显高于交界性组(28.57 %)及良性组(9.09 %)(P<0.01)。在恶性组中临床晚期患者p53阳性表达率(89.29 %)高于早期患者(50.00 %)(P<0.01);在不同的病理分级中p53阳性表达率无明显差异。VEGF与p53在卵巢上皮癌中的表达呈正相关,(r =0.571 4,P<0.01)。VEGF、p53表达双阴性患者的3 a生存率66.7 %(2/3)明显高于VEGF 、p53表达双阳性患者20.00 %(5/25)。结论:VEGF与p53表达呈正相关,和卵巢癌生物学特性有关,可作为估计卵巢癌预后的重要因素。Objective: To investigate the association between the expression of vascular endothelial growth factor (VEGF) and p53, and their influence on clinicopathological characteristics and prognostic value in ovarian epithelial cancer. Methods: VEGF, p53 expression were analysed immunohistochemically in a total 73 paraffin-embeded epithelial ovarian tumor tissues. 24 Patients with benign ovarian tumor (BET),7 patients with borderline ovarian tumor (BOT),42 patients with epithelial ovarian cancer (EOC). Results: Positive immunostaining for VEGF was observed in 86.36 % of EOC, which was significantly higher than that of BOT 66.67 %(P <0.005) and BET 37.50 %(P <0.005). Positive immunostaining for p53 was observed in 76.19 % of EOC, which was significantly higher than that of BOT 28.57 %(P <0.01) and BET 9.09 % (P <0.01), in EOC p53 expression in patients at advanced stage was higher than that at early stage (P <0.01). VEGF and p53 expression in patients with epithelial ovarian cancer showed positive correlation, the correlation was 0.571 4 (P <0.01). The VEGF and p53 expression correlated with poor prognosis. Conclusion: VEGF may be regulated by p53. Both of the two factors related to the clinicopathological characteristics and prognostic value in epithelial ovarian carcinoma .

关 键 词：卵巢上皮性癌 血管内皮生长因子 P53 预后 

分 类 号：R737.31[医药卫生—肿瘤]