子宫内膜癌癌组织中ER、PR和nm23的检测及意义  

Detection of ER,PR and nm23 in endometrial carcinoma and its clinical significance

作　　者：严兆华[1] 全铮华[1] 孙显斌[1] 

机构地区：[1]广东医学院附属医院妇产科,广东湛江524001

出　　处：《广东医学院学报》2004年第5期433-435,共3页Journal of Guangdong Medical College

摘　　要：目的:探讨雌激素受体(ER)、孕激素受体(PR)和肿瘤转移抑制基因nm23在子宫内膜癌组织中的表达及临床意义。方法:对107例子宫内膜癌组织中的ER、PR和nm23基因表达采用S-P免疫组织化学的方法进行检测,并对其在不同组织学分级、肌层浸润深度、临床分期和淋巴结转移的阳性表达率进行了比较。结果:(1)ER、PR、nm23在子宫内膜癌组织中的阳性表达率分别是71.0％、65.4％、64.5％。(2)ER:Ⅰ级的阳性表达率与Ⅲ级比较,P<0.01;肌层浸润>1/2的阳性表达率与无肌层浸润和肌层浸润≤1/2的比较,P<0.01;临床Ⅰ、Ⅱ期的阳性表达率与临床Ⅲ、Ⅳ期的比较差异具显著性(P<0.01)。(3)PR:Ⅰ级的阳性表达率与Ⅲ级的比较,P<0.01;肌层浸润>1/2和肌层浸润≤1/2的阳性表达率与无肌层浸润的比较.P均<0.01;临床Ⅰ、Ⅱ期的阳性表达率与临床Ⅲ、Ⅵ期的比较,P<0.05;淋巴结转移阳性的阳性表达率与淋巴结转移阴性的比较,P<0.05。(4)nm23:Ⅰ级、Ⅱ级的阳性表达率与Ⅲ级的比较,P<0.01;临床Ⅰ、Ⅱ期的阳性表达率与临床Ⅲ、Ⅳ期的比较,P<0.05;淋巴结转移阳性的阳性表达率与淋巴结转移阴性的比较,P<0.05。结论:.ER、PR、nm23的检测可作为子宫内膜癌生物学行为的指标之一,可作为子宫内膜癌术前或(和)术后的治疗参考。Objective: To investigate the expression of estrogen receptor (ER) ,progestogen receptor (PR) and anti-metastasis gene-nm23 in endometrial carcinoma and its clinical significance. Methods: Expression of ER籔R and nm23 in 107 endometrial carcinomas was detected by S-P immunohistochetnical method. Results: The expression rates of ER,PR and nm23 in endometrial cacinoma were 71. 0%, 65. 4%,64. 5%, respectively. There was a statistical difference in expression of ER,PR and nm23 in histological grade and clinical stage (P<0. 05). ER and PR expression rather than nm23 expression was correlated with myometrial infiltration (P<0. 01) , whereas PR and nm 23 expression except for ER was correlated with lymph node metastasis (P<0. 05). Conclusion: Expression of ER. PR and nm23 is helpful in evaluating the biological behavior of endometrial cacinoma.

关 键 词：子宫内膜癌 免疫组织化学 雌激素受体 孕激素受体 NM23 

分 类 号：R737.33[医药卫生—肿瘤]