放疗对狗下颌纯钛种植体与骨接触作用的影响  

The effect of radiation on osseointegration of titanium implants in dog mandibles

作　　者：路正刚[1] 刘洪臣[1] 王所亭[2] 吴殿久[2] 王会信[3] 王东胜[1] 

机构地区：[1]解放军总医院口腔科,主治医师北京100853 [2]解放军总医院放疗科,高级工程师北京100853 [3]解放军军事医学科学院三所八室,教授北京100853

出　　处：《口腔颌面修复学杂志》2004年第3期168-171,i001,共5页Chinese Journal of Prosthodontics

摘　　要：目的:观察放疗对狗下颌纯钛种植体与骨接触作用的影响。方法:8只成年雄性杂种狗,拔除双侧下颌第3、4前磨牙和第1磨牙,形成无牙区。拔牙后3个月,用电子直线加速器照射一侧下颌无牙区,单一剂量15Gy。另一侧不接受照射,作为对照。放疗后3个月,狗双侧下颌无牙区各植入纯钛种植体4枚,其中两枚种植体无任何辅助治疗措施。种植术后1.5个月和3个月分别处死2只动物取材。结果:放疗侧种植体的种植体-骨接触率与对照侧相比,有明显下降,在统计学上有显著差异(P=0.0001<0.01);放疗后种植体周围骨小梁体积百分比具体数值下降,统计学上差异不明显(P=0.071>0.05)。结论:放疗会影响狗下颌纯钛种植体与骨的接触作用。Objective: To evaluate the effect of radiation on osseointegration of titanium implants in dog mandibles. Methods: Eight dogs were divided into two groups. One side of each mandible was irradiated with a single 15-Gy dose. The other side served as control. After another two months, the dogs were divided into two groups. One group received the adjunctive hyperbaric oxygen (HBO) therapy before and after implants insertion. The other group did not . Three months after irradiation , four titanium implants were inserted in each side of the mandible. Two of them were placed without any adjunctive treatment. The dogs were sacrificed at 1.5 and 3 months after implants inserted. Result: BCSR of implants in irradiated sides was significiantly lower than in nonirradiated sides ( P = 0.0001 < 0.01). The quantity of the trabecular bone around implants in irradiated sides was not significiantly lower than in nonirradiated sides ( P = 0.071 >0.05). Conclusion: Radiation can affect the osseointegration of titanium implants in dog mandibles.

关 键 词：下颌 纯钛种植体 放疗后 双侧 对照 影响 照射 作用 前磨牙 拔牙后 

分 类 号：R783[医药卫生—口腔医学] R782[医药卫生—临床医学]