妥泰与丙戊酸钠治疗小儿癫癎临床及脑电图对比研究  

A CONTRAST STUDY ON CLINIC AND EEG IN TREATING CHILDHOOD EPILEPSY WITH TOPIRAMATE AND SODIUM VALPROATE

作　　者：王淑娟[1] 孙秀芳[1] 刘佩云[1] 张贵君[1] 刘英高[1] 

机构地区：[1]青岛大学医学院附属医院神经内科,266003

出　　处：《现代电生理学杂志》2004年第3期133-134,共2页Journal of Modern Electrophysiology

摘　　要：目的:比较妥泰与丙戊酸钠治疗儿童癫痫的疗效。方法:妥泰组40例,男22例, 女18例;丙戊酸钠组44例,男28例,女16例。妥泰剂量逐渐增至4-8mg/(kg·d),丙戊酸 钠逐渐增量至20-30mg/(kg·d)。治疗6个月后评定疗效及脑电图改变。结果:两组比较临 床疗效及脑电图改变无明显差异。结论:妥泰可治疗儿童癫癎。Objective:To compare effects between topiramate and sodium valproate in treating childhood epilepsy. Methods:Topiramate group ( male:22 patients, female: 18 patients) was compared with sodium valproate group (male 28, female 16) in antiepileptic effect of childhood epilepsy. Dosages of topiramate were increased gradually to 4-8 mg/( kg·d). Dosages of sodium valproate were increased gradually to 20-30mg/ (kg·d) Their curative effects and EEG were analysed after 6 months treated. Results: There were not significant difference in clinical effects and EEG changes between two drugs. Conclusion: Topiramate was one effective antiepileptic drug in treatment of childhood Epilepsy.

关 键 词：妥泰 丙戊酸钠 治疗 小儿 脑电图改变 儿童 癫痫 临床 对比研究 差异 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]