影响光动力疗法治疗脉络膜新生血管视力预后的多因素分析  

Multi-factor analysis of the effects on visual acuity prognosis of photodynamic therapy for choroidal neovascularization

作　　者：张力[1] 赵明威[1] 黎晓新[1] 姜燕荣[1] 吕永顺[1] 

机构地区：[1]北京大学人民医院眼科,100044

出　　处：《中华眼底病杂志》2004年第5期292-294,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的　探讨影响光动力疗法 (PDT)治疗脉络膜新生血管 (CNV)治疗后患者远视力的相关因素。　方法　观察 135例 (135只眼 )行 PDT治疗的 CNV患者 ,记录性别、治疗前远视力、治疗前近视力、病程、病因、CNV面积、CNV荧光素眼底血管造影 (FFA)分型、CNV治疗后 FFA变化等 8项因素 ,运用SPSS统计软件 ,分别在治疗后 1个月和 3个月进行视力的多因素相关回归分析。　结果　在治疗后 1个月内远视力与治疗前远视力、CNV的面积、CNV治疗后 FFA变化相关 (P=0 .0 0 0 ,0 .0 30 ,0 .0 6 2 ) ;在治疗后3个月与治疗前远、近视力与 CNV治疗后 FFA变化相关 (P=0 .0 0 0 ,0 .0 5 4 ,0 .0 34) ;在治疗后 1个月内远视力是否提高与 CNV的 FFA分型、病程有关 (P=0 .0 18,0 .0 80 )。　结论　CNV面积较小的患者会获得较好的治疗后视力 ;典型性 CNV患者治疗后视力提高的比例较大 ;Objective To investigate the related factors of effects on distant visual acuity after photodynamic therapy (PDT) for choroidal neovascularization (CNV). Methods One hundred and thirty-five cases (135 eyes) of CNV treated with PDT were observed. The gender, preoperative distant and near visual acuity, disease course, pathogeny, area of CNV, types of CNV ascertained by fundus fluorescein angiography (FFA), and changes of CNV in FFA were recorded. Multi-factor regression analysis of visual acuity within 1 month and 3 months after PDT was performed with SPSS statistics software. Results The distant visual acuity within 1 month postoperatively was related to the preoperative distant visual acuity, the area of CNV and the changes in the FFA(P=0.000,0.030,0.062), and 3 months after PDT, it was related to the distant and near visual acuity preoperatively and the changes in the FFA(P=0.000,0.054,0.034). The condition of distant visual acuity within 1 month postoperatively was related to the FFA type of CNV and the disease course(P =0.018,0.08). Conclusion The smaller the area of CNV is, the better postoperative distant visual acuity would be. The proportion of improvement of visual acuity is relatively higher in patients with classic CNV. Early treatment for the patients with the indicatio may improve the visual acuity effectively.

关 键 词：CNV 治疗后 FFA 患者 治疗前 远视力 光动力疗法 面积 典型性 

分 类 号：R773.4[医药卫生—眼科]