肺亲肿瘤显像鉴别良恶性病变的观察  

The Study of Differentiating Malingnant from Benign Lesinos with Lung Turnoravidity Imaging

作　　者：陈萍[1] 叶广春[1] 朱卫国[1] 梁伟坚[1] 武虹[2] 成向阳[3] 

机构地区：[1]广州医学院第一附属医院核医学教研室,广州510120 [2]广州医学院第一附属医院病理科,广州510120 [3]广州医学院第一附属医院胸外科,广州510120

出　　处：《现代临床医学生物工程学杂志》1996年第1期18-20,共3页Journal of Modern Clinical Medical Bioengineering

摘　　要：71例诊断为肺部肿瘤的患者,进行了^(99m)Tc-MIBI^(99m),Tc-Glu^(99m),Tc-HMPAO,肺亲肿瘤显像。检出率各为77.8％,50％,80％;准确率各为90.8％,58.3％,和80％;特异性各为70％,14.3％,0％。SPECT显像对肺小肿瘤检出率明显高于平面显像,^(99m)Tc-MIBI检出最小肿物为1.5cm。纵隔淋巴转移,锁骨上淋巴转移部位可清楚显示,注射后2小时延迟SPECT显像比早期SPECT显像更易揭示肺恶性病变,^(99m)Tc-MIBI对5例肺癌合并陈旧结核病人的病灶能清晰显示而结核病灶未见显影。结果证明在肺部疾病中^(99m)Tc-MIBI是有亲肺癌特征,并有可能用于肺良恶性病变的鉴别诊断。We performed Tc-MIBI, Tc-Glu,Tc-HMPAO lung tumoravidity imaging in 71 Patients with lung tumor diagnosed by X-Ray, CT, MRI. The finding of three phase and SPECT images were compared with the reports of pathological diagnosis (as a standard) to calculate detecting rate, accuracy and specificity. The results show in table. Table: To compare the detecting rate, accuracy and specificity of three lung lumoravidity radioactive Pharmaceuticals in patients with lung tumor Tc-MIBI Tc-GLU TC-HMPAO Detecting rate Accuracy specificity 77.8%(42/54) 90.8%(49/54) 70%(7/10) -50%(6/12) 58.3%(7/12) 14.3%(l/7) 80%(4/5) 80%(4/5) 0%(0/1) Detecting rate of small lung tumor, SPECT imaging was siginficantly higher than that of planar imaging. The smallest tumor detecting by To-MIBI imanging was 1.5 cm in diameter. By SPECT imaging metastasis of mediastinal lymph nodes and supraclavicular lymph nodes were detected clearly. Delayed (2hrs after injection) SPECT imaging exposed pulmonary nodule easier than that of early (15min after injection) SPECT imaging. 'Tc - tuberculous lesion was not imaged. Our results comfirmed that Tc -MIBI had a character of lung cancer -avidity, and it can be used in differCntating malignant from benign lesions in the lung disease. 99nTc-MIBI = 99mTechnetium Methyloxyl Iso-Butal Isocyanide 99nTc-Glu = 99mTechnetium Calcium Gluconate 99raTc-HMPAO = 99mTechnetiuni Hexa-methyl propylcne amine-Oxime

关 键 词：肺亲肿瘤显像 甲氧异丁腈 葡萄糖酸钙 六甲基丙二胺肟 肺肿瘤 病变程度 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]