乳酸左氧氟沙星的紫外光谱性质与应用  

ULTRAVIOLET SPECTRUM PROPERTY OF EVOFLOXACINLACTATE AND ITS APPLICATION

作　　者：张国文[1] 潘军辉[2] 黄璞[2] 倪永年[3] 

机构地区：[1]南昌大学食品科学教育部重点实验室,江西南昌330047 [2]南昌大学食品科学与工程系,江西南昌330047 [3]南昌大学化学系,江西南昌330047

出　　处：《南昌大学学报（理科版）》2004年第3期240-242,共3页Journal of Nanchang University(Natural Science)

基　　金：江西省自然科学基金资助项目(0320014);南昌大学科研基金(NCX0288)资助项目

摘　　要：在不同pH(1.89-11.58)的Britton-Robinson(B-R)缓冲溶液中,乳酸左氧氟沙星的紫外光谱性质,并对其吸收光谱的移动进行了详细的探讨。提出pH=2.87为分光光度法测定乳酸左氧氟沙星的最佳酸度,在最大吸收波长292nm处,测得其表观摩尔吸光系数为3.4×104L·mol-1·cm-1。乳酸左氧氟沙星的线性范围为1.0-23.0mg·L-1,检出限为0.565mg·L-1。该法成功用于药物制剂中乳酸左氧氟沙星含量的测定,结果满意。In the pH range of 1.89 - 11.58 Britton-Robinson buffer solutions, the Levofloxacin lactate ultraviolet spectrum property was studied , and the reason of the absorption spectra shift was discussed. The best condition in detecting Levofloxacin lactate by ultraviolet spectrophotometry is proposed. The absorption maxima of the drug lies at 292 nm, The linear range of Levofloxacin lactate is 1.0-23.0 mg·L^(-1), the limit of detection is 0.565 mg·L^(-1), and the apparent molar absorptivity is 3.4×10~4 L· mol^(-1)· cm^(-1).The method was successfully applied to the determination of Levofloxacin lactate in tabloids with satisfied results.

关 键 词：乳酸左氧氟沙星 药物制剂 紫外光谱 含量 最大吸收波长 分光光度法 功用 谱性质 吸收光谱 缓冲溶液 

分 类 号：O177[理学—数学] R969[理学—基础数学]