LFO方案治疗晚期胃肠道癌近期疗效观察  

The observation of LFO therapy effect in advanced gastrointestinal cancer

作　　者：陈占红[1] 张沂平[1] 孙琳[1] 钟海均[1] 叶魏武[1] 

机构地区：[1]浙江省肿瘤医院化疗中心,310022

出　　处：《浙江临床医学》2004年第10期855-856,共2页Zhejiang Clinical Medical Journal

摘　　要：目的 观察LFO方案治疗晚期胃肠道癌的近期疗效。 方法 采用甲酰四氢叶酸钙 (CF)、5 -氟尿嘧啶 (5-FU )及草酸铂(OXA)即LFO方案静脉输注。以3～4周为1周期 ,2个周期以上评定疗效并观察毒副反应。结果 全组48例 ,总有效率为50.0 % ,其中 ,CR5例 ,PR19例。不良反应主要是肢端感觉异常、血象改变、胃肠道反应。结论 LFO方案治疗晚期胃肠道癌有效率较高 。Objective To evaluate the therapy efficacy of LFO(leucovorin,5-fluorouracil and oxaliplatin)in advanced gastrointestinal cancer. Methods Patients of advanced gastrointestinal cancer were treated with LFO program(1cycle during3～4weeks).The therapy effect and ill effect of programLFO were evaluated in more than2cycles. Results The total efficient rate of48patients evaluated was50.0%.5cases were CR and19cases were PR.The main ill effect of LFO were acroparesthesia,blood routine change and gastrointestinal discomfort. Conclusion LFO was efficient to advanced gastrointestinal cancer and was worth of further clinic observation.

关 键 词：方案治疗 晚期胃肠道癌 近期疗效观察 总有效率 感觉异常 静脉输注 胃肠道反应 

分 类 号：R735[医药卫生—肿瘤] R521[医药卫生—临床医学]